[gastric Emptying And Metabolic Acidosis. I. Study Of An Experimental Model In Rats, Using An Ammonium Chloride Solution Administered Through The Orogastric Route].

dc.creatorBelangero, V M
dc.creatorCollares, E F
dc.date
dc.date2015-11-27T12:19:16Z
dc.date2015-11-27T12:19:16Z
dc.date.accessioned2018-03-29T00:52:51Z
dc.date.available2018-03-29T00:52:51Z
dc.identifierArquivos De Gastroenterologia. v. 28, n. 4, p. 145-50
dc.identifier0004-2803
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/1843251
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194191
dc.identifier1843251
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294424
dc.descriptionThe goal of the study was get an experimental model of metabolic acidosis which was appropriated in future gastric emptying studies. For this proposal were utilized 141 female Wistar rats in three stages: in the first (n = 27) was defined the installation, manutention and spontaneous recuperation of the metabolic acidosis produced by the orogastric infusion of a two ml by 100 g of an 0.5 M ammonium chloride solution; in the second (n = 60), it was studied the gastric emptying of the same solution utilized in the first stage and in the last stage (n = 54) it was determined the gastric emptying of the water, for excluding the possibility that the acidificant solution had caused any lesion in the gastric mucosa. As control group were utilized animals fed as a sodium chloride solution in the same concentration and volume that the acidificant solution. The results showed that 6 hours after the infusion, the gastric emptying of two above mentioned meals was complete and there was still a moderate metabolic acidosis in the group with infusion of ammonium chloride solution. Further more, the metabolic acidosis persisted in moderate values until 8 hours after the infusion. Based on these data the interval between 6 and 8 hours after the infusion of the these solutions was considered the best to the further studies about metabolic acidosis and gastric emptying. Finally, the gastric emptying of water, studied in rats with acidosis and controls demonstrated no differences between them. This was interpreted as a clue that the ammonium chloride solution did not modificate the integrity of the gastric mucosa.
dc.description28
dc.description145-50
dc.languagepor
dc.relationArquivos De Gastroenterologia
dc.relationArq Gastroenterol
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAcidosis
dc.subjectAdministration, Oral
dc.subjectAmmonium Chloride
dc.subjectAnimals
dc.subjectBlood Gas Analysis
dc.subjectDisease Models, Animal
dc.subjectFemale
dc.subjectGastric Emptying
dc.subjectGastric Mucosa
dc.subjectHypertonic Solutions
dc.subjectIntubation, Gastrointestinal
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSaline Solution, Hypertonic
dc.subjectTime Factors
dc.title[gastric Emptying And Metabolic Acidosis. I. Study Of An Experimental Model In Rats, Using An Ammonium Chloride Solution Administered Through The Orogastric Route].
dc.typeArtículos de revistas


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