Ethanol Reduces The Endothelin-b Receptor-mediated Increase In Portal Inflow Resistance In The Isolated, Perfused Canine Liver.

dc.creatorFaro, F
dc.creatorFerraz, J G
dc.creatorStella, H J
dc.creatorFaro, R
dc.creatorAntunes, E
dc.creatorOpgennorth, T J
dc.creatorWithrington, P G
dc.creatorde Nucci, G
dc.date1998
dc.date2015-11-27T12:19:13Z
dc.date2015-11-27T12:19:13Z
dc.date.accessioned2018-03-29T00:52:45Z
dc.date.available2018-03-29T00:52:45Z
dc.identifierJournal Of Cardiovascular Pharmacology. v. 31 Suppl 1, p. S284-6, 1998.
dc.identifier0160-2446
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9595460
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194167
dc.identifier9595460
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294400
dc.descriptionEthanol can affect the regulation of liver hemodynamics through the release of vasoactive mediators such as nitric oxide and endothelins (ETs). The purpose of this study was to investigate the effects of ethanol on the changes in arterial and portal perfusion pressure induced by ET receptor activation. Ethanol significantly reduced portal, but not arterial perfusion pressure. ET-1 and norepinephrine (used as an ET receptor-independent vasoconstrictor) induced changes in hepatic arterial or portal inflow resistance that were not affected by ethanol treatment. However, an IRL 1620-induced increase in portal, but not arterial, inflow resistance was significantly reduced in ethanol-perfused preparations, an effect observed after either intra-arterial or intraportal administration of the agonist. These results suggest that ethanol can diminish the responsiveness of the portal vascular bed of the canine liver to ETB receptor activation.
dc.description31 Suppl 1
dc.descriptionS284-6
dc.languageeng
dc.relationJournal Of Cardiovascular Pharmacology
dc.relationJ. Cardiovasc. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdrenergic Alpha-agonists
dc.subjectAnimals
dc.subjectCentral Nervous System Depressants
dc.subjectDogs
dc.subjectEndothelin Receptor Antagonists
dc.subjectEndothelin-1
dc.subjectEndothelins
dc.subjectEthanol
dc.subjectLiver Circulation
dc.subjectNorepinephrine
dc.subjectPeptide Fragments
dc.subjectPortal Pressure
dc.subjectReceptor, Endothelin A
dc.subjectReceptor, Endothelin B
dc.subjectReceptors, Endothelin
dc.subjectVascular Resistance
dc.titleEthanol Reduces The Endothelin-b Receptor-mediated Increase In Portal Inflow Resistance In The Isolated, Perfused Canine Liver.
dc.typeArtículos de revistas


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