Timing Of Onset Of Contraceptive Effectiveness In Depo-provera Users: Part I. Changes In Cervical Mucus.

dc.creatorPetta, C A
dc.creatorFaundes, A
dc.creatorDunson, T R
dc.creatorRamos, M
dc.creatorDeLucio, M
dc.creatorFaundes, D
dc.creatorBahamondes, L
dc.date1998-Feb
dc.date2015-11-27T12:19:10Z
dc.date2015-11-27T12:19:10Z
dc.date.accessioned2018-03-29T00:52:39Z
dc.date.available2018-03-29T00:52:39Z
dc.identifierFertility And Sterility. v. 69, n. 2, p. 252-7, 1998-Feb.
dc.identifier0015-0282
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9496338
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194137
dc.identifier9496338
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294370
dc.descriptionTo evaluate the changes in cervical mucus within the first hours or days after depot medroxyprogesterone acetate (MPA) injection so as to estimate the time at which cervical mucus becomes hostile enough to prevent pregnancy. Multicenter, clinical descriptive study. Family planning clinic. Thirty women who were between days 8 and 13 of their menstrual cycle and who had requested Depo-Provera were enrolled in the study. Cervical mucus and blood samples were obtained; transvaginal ultrasonography was performed. Cervical mucus scores, sperm penetration distances, ovarian follicular size, and serum levels of progesterone and estradiol. From 6 to 24 hours after injection, there was a sharp decline in the cervical mucus score for most of the subjects. All subjects exhibited poor mucus on day 3 after injection, and by day 7, all subjects had zero scores, with the exception of two outliers on each day. Sperm penetration, as measured by the vanguard sperm distance, was already poor (< 1 cm) in 7 of the 30 subjects at the time of injection and was reduced progressively up to 24 hours after injection, when only four subjects had a sperm penetration of > 1 cm. A rapid decline in the estimated number of sperm was observed at 12 hours and more so at 24 hours in the majority of subjects. The data presented in this report confirmed that depot MPA causes profound changes in cervical mucus after injection. Although very little change was seen at 6 hours, alterations were observed subsequently, with 90% of the subjects showing a poor cervical mucus score 24 hours after administration of the progestin. No reliable clinical marker is available to identify in which women depot MPA might exert its effect on cervical mucus within 3 days. Thus, we believe that at present, women should be informed of this uncertainty and should use a backup method of contraception for 7 days when the first injection of depot MPA is provided after the seventh day of the menstrual cycle.
dc.description69
dc.description252-7
dc.languageeng
dc.relationFertility And Sterility
dc.relationFertil. Steril.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectCervix Mucus
dc.subjectContraceptive Agents, Female
dc.subjectFemale
dc.subjectFollow-up Studies
dc.subjectHumans
dc.subjectMale
dc.subjectMedroxyprogesterone Acetate
dc.subjectSpermatozoa
dc.subjectTime Factors
dc.subjectAcceptors
dc.subjectAcceptors, New--women
dc.subjectAmericas
dc.subjectBiology
dc.subjectBrazil
dc.subjectCervical Mucus
dc.subjectCervix
dc.subjectClinical Research
dc.subjectContraception
dc.subjectContraceptive Agents, Female--pharmacodynamics
dc.subjectContraceptive Agents, Progestin--pharmacodynamics
dc.subjectContraceptive Agents--pharmacodynamics
dc.subjectContraceptive Methods
dc.subjectContraceptive Mode Of Action
dc.subjectDemographic Factors
dc.subjectDepo-provera--pharmacodynamics
dc.subjectDeveloping Countries
dc.subjectFamily Planning
dc.subjectFamily Planning Programs
dc.subjectGenitalia
dc.subjectGenitalia, Female
dc.subjectInhibition Of Fertilization
dc.subjectInjectables
dc.subjectLatin America
dc.subjectMedroxyprogesterone Acetate--pharmacodynamics
dc.subjectPhysiology
dc.subjectPopulation
dc.subjectPopulation Dynamics
dc.subjectResearch Methodology
dc.subjectResearch Report
dc.subjectSouth America
dc.subjectSperm Transport Inhibition
dc.subjectTime Factors
dc.subjectUrogenital System
dc.subjectUterus
dc.titleTiming Of Onset Of Contraceptive Effectiveness In Depo-provera Users: Part I. Changes In Cervical Mucus.
dc.typeArtículos de revistas


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