Regulation Of Insulin-stimulated Tyrosine Phosphorylation Of Shc And Irs-1 In The Muscle Of Rats: Effect Of Growth Hormone And Epinephrine.

dc.creatorThirone, A C
dc.creatorPaez-Espinosa, E V
dc.creatorCarvalho, C R
dc.creatorSaad, M J
dc.date1998-Jan
dc.date2015-11-27T12:19:09Z
dc.date2015-11-27T12:19:09Z
dc.date.accessioned2018-03-29T00:52:37Z
dc.date.available2018-03-29T00:52:37Z
dc.identifierFebs Letters. v. 421, n. 3, p. 191-6, 1998-Jan.
dc.identifier0014-5793
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9468304
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194130
dc.identifier9468304
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294363
dc.descriptionInsulin receptor substrate-1 (IRS-1) and Shc protein have the same binding site at the insulin receptor and compete in their association with the phosphorylated receptor. The present study demonstrates that a decrease in the level of muscle insulin receptor phosphorylation induced by chronic growth hormone (GH) treatment or acute epinephrine infusion is accompanied by a reduction in the level of IRS-1 phosphorylation and in the association with phosphatidylinositol 3-kinase. In contrast, no change is observed in insulin-stimulated Shc tyrosine phosphorylation, or in the association of this substrate with Grb2. These data suggest that a reduction in insulin receptor phosphorylation may affect post-receptor processes differentially by preserving the phosphorylation of some substrates and pathways, but not of others.
dc.description421
dc.description191-6
dc.languageeng
dc.relationFebs Letters
dc.relationFEBS Lett.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAmino Acid Sequence
dc.subjectAnimals
dc.subjectEpinephrine
dc.subjectHindlimb
dc.subjectHuman Growth Hormone
dc.subjectInsulin
dc.subjectInsulin Receptor Substrate Proteins
dc.subjectMale
dc.subjectMolecular Sequence Data
dc.subjectMuscles
dc.subjectPhosphoproteins
dc.subjectPhosphorylation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTyrosine
dc.titleRegulation Of Insulin-stimulated Tyrosine Phosphorylation Of Shc And Irs-1 In The Muscle Of Rats: Effect Of Growth Hormone And Epinephrine.
dc.typeArtículos de revistas


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