Phoneutria Nigriventer Spider Venom Induces Oedema In Rat Skin By Activation Of Capsaicin Sensitive Sensory Nerves.

dc.creatorCosta, S K
dc.creatorde Nucci, G
dc.creatorAntunes, E
dc.creatorBrain, S D
dc.date1997-Nov
dc.date2015-11-27T12:19:04Z
dc.date2015-11-27T12:19:04Z
dc.date.accessioned2018-03-29T00:52:27Z
dc.date.available2018-03-29T00:52:27Z
dc.identifierEuropean Journal Of Pharmacology. v. 339, n. 2-3, p. 223-6, 1997-Nov.
dc.identifier0014-2999
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9473139
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194089
dc.identifier9473139
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294322
dc.descriptionPhoneeutria nigriventer venom induces oedema formation when injected in the rat dorsal skin and such oedema is, in part, dependent on the stimulation of tachykinin NK1 receptors. This study investigated whether Phoneutria nigriventer venom acts directly on tachykinin NK1 receptors, or indirectly to activate sensory neurones which in turn release a tachykinin NK1 receptor agonist. The plasma extravasation induced by Phoneutria nigriventer venom (1-10 microg/site) in neonatally capsaicin (8-methyl N-vanillyl-6-nonenamide)-pretreated rats was substantially attenuated (P < 0.05) but the response to either the tachykinin NK1 receptor agonist GR73632 ((deltaAva[L-Pro9, N-MeLeu10] substance P-(7-11) 30 pmol/site) or bradykinin (0.3-3 nmol/site) was not affected. These results indicate that Phoneutria nigriventer venom stimulates sensory nerves indirectly. The lack of effect of capsaicin-pretreatment on the GR73632 and bradykinin responses indicated that the tachykinin NK1 and bradykinin B2 receptors remained functional. There was no evidence to suggest that Phoneutria nigriventer venom contains a tachykinin NK1 receptor agonist.
dc.description339
dc.description223-6
dc.languageeng
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectBlood Pressure
dc.subjectBlood Proteins
dc.subjectCapsaicin
dc.subjectEdema
dc.subjectFemale
dc.subjectMale
dc.subjectNervous System
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Tachykinin
dc.subjectSkin Diseases
dc.subjectSpider Venoms
dc.subjectSpiders
dc.titlePhoneutria Nigriventer Spider Venom Induces Oedema In Rat Skin By Activation Of Capsaicin Sensitive Sensory Nerves.
dc.typeArtículos de revistas


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