A Double-blind Controlled Clinical Trial Of Oxcarbazepine Versus Phenytoin In Children And Adolescents With Epilepsy.

dc.creatorGuerreiro, M M
dc.creatorVigonius, U
dc.creatorPohlmann, H
dc.creatorde Manreza, M L
dc.creatorFejerman, N
dc.creatorAntoniuk, S A
dc.creatorMoore, A
dc.date1997-Jun
dc.date2015-11-27T12:18:59Z
dc.date2015-11-27T12:18:59Z
dc.date.accessioned2018-03-29T00:52:16Z
dc.date.available2018-03-29T00:52:16Z
dc.identifierEpilepsy Research. v. 27, n. 3, p. 205-13, 1997-Jun.
dc.identifier0920-1211
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9237055
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194041
dc.identifier9237055
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294274
dc.descriptionIn many countries oxcarbazepine (OXC) has been registered for use as first-line and add-on treatment for patients with partial seizures with or without secondarily generalized seizures (PS) and generalized tonic-clonic seizures without partial onset (GTCS). Its use as monotherapy in children and adolescents with newly diagnosed epilepsy was investigated in this double-blind, randomized, parallel-group comparison with phenytoin (PHT). A total of 193 patients aged 5-18 years with either PS or GTCS were enrolled. After a retrospective baseline assessment, patients were randomized to OXC or PHT in a 1:1 ratio. The double-blind treatment phase comprised two periods: an 8-week flexible titration period; followed by 48 weeks maintenance treatment. In the efficacy analyses, there were no statistically significant differences between OXC and PHT. Forty-nine (61%) patients in the OXC group and 46 (60%) in the PHT group were seizure-free during the maintenance period. In total, 24 patients in the OXC group discontinued treatment prematurely (two for tolerability reasons) compared with 34 in the PHT group (14 for tolerability reasons). The number of premature discontinuations due to adverse experiences was statistically significantly lower in the OXC group than in the PHT group. Moreover, the odds of an individual discontinuing prematurely (regardless of reason) were almost twice as high in the PHT group. This trial provides further support for the efficacy and safety of OXC as first-line treatment in children and adolescents with PS and GTCS. In addition, the results show that OXC in these patients has significant advantages over PHT in terms of tolerability and treatment retention.
dc.description27
dc.description205-13
dc.languageeng
dc.relationEpilepsy Research
dc.relationEpilepsy Res.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAnticonvulsants
dc.subjectCarbamazepine
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDouble-blind Method
dc.subjectEpilepsies, Partial
dc.subjectEpilepsy, Generalized
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectPhenytoin
dc.titleA Double-blind Controlled Clinical Trial Of Oxcarbazepine Versus Phenytoin In Children And Adolescents With Epilepsy.
dc.typeArtículos de revistas


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