N-ras Gene Point Mutations In Brazilian Acute Myelogenous Leukemia Patients Correlate With A Poor Prognosis.

dc.creatorDe Melo, M B
dc.creatorLorand-Metze, I
dc.creatorLima, C S
dc.creatorSaad, S T
dc.creatorCosta, F F
dc.date1997-Jan
dc.date2015-11-27T12:18:57Z
dc.date2015-11-27T12:18:57Z
dc.date.accessioned2018-03-29T00:52:13Z
dc.date.available2018-03-29T00:52:13Z
dc.identifierLeukemia & Lymphoma. v. 24, n. 3-4, p. 309-17, 1997-Jan.
dc.identifier1042-8194
dc.identifier10.3109/10428199709039018
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9156660
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194024
dc.identifier9156660
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294257
dc.descriptionThe frequency of ras gene mutations varies from 11 to 27% in AML populations from the United States and Europe but it seems that there is no study regarding the frequency of mutated N-ras gene in patients with AML in South America. In order to study the frequency of N-ras gene mutations (exons 1 and 2) in Brazilian patients with AML and to evaluate the possible correlation between the presence of the mutation and clinical features, 40 patients were analyzed. N-ras mutations were identified in DNA samples from eight of 40 AML patients (20%). No significant correlation was found between N-ras mutation and age, sex, race, response to therapy, FAB subtype or occupational exposure. However, the overall survival and AML-free survival were significantly shorter in patients with N-ras mutations than in those without these abnormalities.
dc.description24
dc.description309-17
dc.languageeng
dc.relationLeukemia & Lymphoma
dc.relationLeuk. Lymphoma
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAcute Disease
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectBrazil
dc.subjectContinental Population Groups
dc.subjectDna, Neoplasm
dc.subjectExons
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenes, Ras
dc.subjectHumans
dc.subjectLeukemia, Myeloid
dc.subjectLife Tables
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPoint Mutation
dc.subjectPrognosis
dc.subjectSurvival Analysis
dc.subjectTreatment Outcome
dc.titleN-ras Gene Point Mutations In Brazilian Acute Myelogenous Leukemia Patients Correlate With A Poor Prognosis.
dc.typeArtículos de revistas


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