Acute Inhibition Of Nitric Oxide Synthesis Induces Anxiolysis In The Plus Maze Test.

dc.creatorFaria, M S
dc.creatorMuscará, M N
dc.creatorMoreno Júnior, H
dc.creatorTeixeira, S A
dc.creatorDias, H B
dc.creatorDe Oliveira, B
dc.creatorGraeff, F G
dc.creatorDe Nucci, G
dc.date1997-Mar
dc.date2015-11-27T12:18:56Z
dc.date2015-11-27T12:18:56Z
dc.date.accessioned2018-03-29T00:52:10Z
dc.date.available2018-03-29T00:52:10Z
dc.identifierEuropean Journal Of Pharmacology. v. 323, n. 1, p. 37-43, 1997-Mar.
dc.identifier0014-2999
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9105874
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194017
dc.identifier9105874
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294250
dc.descriptionThe involvement of nitric oxide (NO) in anxiety was investigated in rats, using the elevated plus maze test. Acute, but not chronic, systemic treatment with N omega-nitro-L-arginine methyl ester (L-NAME, 10 and 60 mg.kg-1), an inhibitor of NO synthase, increased the time spent by the rats in the open arms. Both the acute and chronic treatments with L-NAME inhibited NO synthase in endothelial cells and in the central nervous system, as shown by the increase in mean arterial pressure and decreased NO synthase activity in brain tissue. Chronic treatment with L-NAME also decreased the serum nitrate levels. The anxiolysis induced by acute L-NAME treatment is unlikely to be due to hypertension, since two-kidney one-clip hypertension in non-L-NAME-treated rats failed to significantly change exploratory behaviour in the elevated plus maze. These results indicate that acute inhibition of NO synthesis decreases anxiety in rats.
dc.description323
dc.description37-43
dc.languageeng
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnalysis Of Variance
dc.subjectAnimals
dc.subjectAnti-anxiety Agents
dc.subjectAnxiety
dc.subjectArginine
dc.subjectBlood Pressure
dc.subjectBrain
dc.subjectCentral Nervous System
dc.subjectDiazepam
dc.subjectEnzyme Inhibitors
dc.subjectHypertension, Renal
dc.subjectMale
dc.subjectMaze Learning
dc.subjectNg-nitroarginine Methyl Ester
dc.subjectNitrates
dc.subjectNitric Oxide
dc.subjectNitric Oxide Synthase
dc.subjectRats
dc.subjectRats, Wistar
dc.titleAcute Inhibition Of Nitric Oxide Synthesis Induces Anxiolysis In The Plus Maze Test.
dc.typeArtículos de revistas


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