Rapid Detection Of Factor V Leiden (fvq506) By Non-radioactive Single Strand Conformation Polymorphism (sscp).

dc.creatorArruda, V R
dc.creatorvon Zuben, P M
dc.creatorAnnichino-Bizzachi, J M
dc.creatorCosta, F F
dc.date1996-Oct
dc.date2015-11-27T12:18:49Z
dc.date2015-11-27T12:18:49Z
dc.date.accessioned2018-03-29T00:51:59Z
dc.date.available2018-03-29T00:51:59Z
dc.identifierSangre. v. 41, n. 5, p. 379-81, 1996-Oct.
dc.identifier0036-4355
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/8986114
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193965
dc.identifier8986114
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294198
dc.descriptionThe transition G-->A at position 506 of the factor V gene is responsible for resistance to the anticoagulant effect of activated protein C (APC-resistance), and represents the most common hereditary risk factor for venous thrombosis. A comparison of the ability of non-radioactive single-strand conformation polymorphism (SSCP) and of a standard PCR procedure followed by further digestion with MnlI to detect this factor V gene (FVQ 506) transition indicates that these is a good agreement between the two methods. Non-radioactive SSCP analysis therefore represents a rapid and sensitive alternative for the diagnosis of this important point mutation.
dc.description41
dc.description379-81
dc.languageeng
dc.relationSangre
dc.relationSangre (Barc)
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectDna Mutational Analysis
dc.subjectDeoxyribonucleases, Type Ii Site-specific
dc.subjectDisease Susceptibility
dc.subjectFactor V
dc.subjectFactor V Deficiency
dc.subjectHumans
dc.subjectPoint Mutation
dc.subjectPolymorphism, Single-stranded Conformational
dc.subjectSilver Staining
dc.subjectThromboembolism
dc.titleRapid Detection Of Factor V Leiden (fvq506) By Non-radioactive Single Strand Conformation Polymorphism (sscp).
dc.typeArtículos de revistas


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