Glutathione Peroxidase, Reduced Glutathione, Superoxide Dismutase And Catalase In Red Cells Of Patients With Hairy Cell Leukemia.

dc.creatorArruda, V R
dc.creatorSalles, T S
dc.creatorCosta, F F
dc.creatorSaad, S T
dc.date1996
dc.date2015-11-27T12:18:46Z
dc.date2015-11-27T12:18:46Z
dc.date.accessioned2018-03-29T00:51:53Z
dc.date.available2018-03-29T00:51:53Z
dc.identifierNeoplasma. v. 43, n. 2, p. 99-102, 1996.
dc.identifier0028-2685
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/8843970
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193937
dc.identifier8843970
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294170
dc.descriptionRed cell antioxidant enzymes have been recently studied in malignant lymphomas and the results are controversial. Hairy cell leukemia is a rare chronic lymphoproliferative disorder originating probably in a pluripotent stem cell. In the present study, glutathione peroxidase (Gpx), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase were measured in a homogeneous group of patients with untreated hairy cell leukemia and normal controls. Glutathione peroxidase, catalase and SOD activities were significantly lower in patients than in normals. GSH was not significantly different in patients compared to controls. There was no correlation between Gpx, GSH, SOD, and catalase and hemoglobin; reticulocytes, leukocytes, hairy cells, platelets number or splenomegaly. Taken together these data suggest a decreased activity of red cell antioxidant enzymes in hairy cell leukemia and support a pluripotent stem cell defect of these abnormalities.
dc.description43
dc.description99-102
dc.languageeng
dc.relationNeoplasma
dc.relationNeoplasma
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectCatalase
dc.subjectErythrocytes
dc.subjectGlutathione
dc.subjectGlutathione Peroxidase
dc.subjectHumans
dc.subjectLeukemia, Hairy Cell
dc.subjectMiddle Aged
dc.subjectSuperoxide Dismutase
dc.titleGlutathione Peroxidase, Reduced Glutathione, Superoxide Dismutase And Catalase In Red Cells Of Patients With Hairy Cell Leukemia.
dc.typeArtículos de revistas


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