Evaluation Of Two Different Oxygen Inspiratory Fractions On The Hemodynamic Effects Of N Omega-nitro-l-arginine Methyl Ester In Anesthetized Dogs.

dc.creatorZappellini, A
dc.creatorMoreno, H
dc.creatorAntunes, E
dc.creatorde-Nucci, G
dc.date1996-Jan
dc.date2015-11-27T12:18:43Z
dc.date2015-11-27T12:18:43Z
dc.date.accessioned2018-03-29T00:51:46Z
dc.date.available2018-03-29T00:51:46Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 29, n. 1, p. 33-9, 1996-Jan.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/8731329
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193912
dc.identifier8731329
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294145
dc.descriptionThe effect of two different oxygen inspiratory fractions (FiO2 = 21% and 100%) on the hemodynamic responses induced by N omega-nitro-L-arginine methyl ester (L-NAME) was investigated in anesthetized dogs. L-NAME (0.01-10.0 mg/kg), but not D-NAME, induced dose-dependent changes in the hemodynamic parameters of the animals. At the highest dose, L-NAME increased mean arterial blood pressure in both room air (from 86.2 +/- 3.2 to 125.1 +/- 7.8 mmHg) and pure oxygen (from 100.0 +/- 7.5 to 139.0 +/- 3.2 mmHg) ventilated animals. L-NAME also increased systemic and pulmonary vascular resistances. These effects were accompanied by a decrease in cardiac output and bradycardia (37% and 31% decreases for pure oxygen and room air, respectively). However, there were no significant differences in the responses to L-NAME between the dogs ventilated with FiO2 = 21% and those ventilated with FiO2 = 100%. L-NAME did not modify blood gas analyses, despite the expected difference in pO2 levels between the two experimental groups of animals (3 times higher in the animals ventilated with pure oxygen). These results indicate that nitric oxide release accounts for the maintenance of hemodynamic function in the anesthetized dog, and that L-NAME-induced effects are not affected by hyperoxemia.
dc.description29
dc.description33-9
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBlood Gas Analysis
dc.subjectBlood Pressure
dc.subjectDogs
dc.subjectFemale
dc.subjectHemodynamics
dc.subjectInspiratory Capacity
dc.subjectMale
dc.subjectNg-nitroarginine Methyl Ester
dc.subjectNitric Oxide
dc.subjectOxygen Consumption
dc.subjectVascular Resistance
dc.titleEvaluation Of Two Different Oxygen Inspiratory Fractions On The Hemodynamic Effects Of N Omega-nitro-l-arginine Methyl Ester In Anesthetized Dogs.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución