Oxidative Damage Of Mitochondria Induced By Fe(ii)citrate Or T-butyl Hydroperoxide In The Presence Of Ca2+: Effect Of Coenzyme Q Redox State.

dc.creatorCastilho, R F
dc.creatorKowaltowski, A J
dc.creatorMeinicke, A R
dc.creatorVercesi, A E
dc.date1995-Jan
dc.date2015-11-27T12:18:36Z
dc.date2015-11-27T12:18:36Z
dc.date.accessioned2018-03-29T00:51:32Z
dc.date.available2018-03-29T00:51:32Z
dc.identifierFree Radical Biology & Medicine. v. 18, n. 1, p. 55-9, 1995-Jan.
dc.identifier0891-5849
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/7896171
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193845
dc.identifier7896171
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294078
dc.descriptionThe role of coenzyme Q on the process of mitochondrial membrane damage associated with oxidative stress was studied in a suspension of uncoupled mitochondria exposed to Ca2+ in the presence of Fe(II)citrate or t-butyl hydroperoxide. Reduction of coenzyme Q by succinate was shown to inhibit both inner membrane lipid peroxidation and permeabilization induced by Fe(II)citrate. In contrast, the inner membrane permeabilization induced by Ca2+ alone or Ca2+ plus t-butyl hydroperoxide was potentiated by the presence of succinate. These results support our previous proposition that the mitochondrial damage associated with oxidative stress generated by these pro-oxidants in the presence of Ca2+ is mediated by different mechanisms.
dc.description18
dc.description55-9
dc.languageeng
dc.relationFree Radical Biology & Medicine
dc.relationFree Radic. Biol. Med.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAntimycin A
dc.subjectButylated Hydroxytoluene
dc.subjectCalcium
dc.subjectFerrous Compounds
dc.subjectFree Radicals
dc.subjectMitochondria, Liver
dc.subjectMitochondrial Swelling
dc.subjectOxidation-reduction
dc.subjectOxidative Stress
dc.subjectPeroxides
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSuccinates
dc.subjectSuccinic Acid
dc.subjectThiobarbituric Acid Reactive Substances
dc.subjectUbiquinone
dc.subjectTert-butylhydroperoxide
dc.titleOxidative Damage Of Mitochondria Induced By Fe(ii)citrate Or T-butyl Hydroperoxide In The Presence Of Ca2+: Effect Of Coenzyme Q Redox State.
dc.typeArtículos de revistas


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