Comparative Bioavailability Of Single Doses Of Tablet Formulations Of Cetirizine Dihydrochloride In Healthy Male Volunteers.

dc.creatorMuscará, M N
dc.creatorde Nucci, G
dc.date1995-Jan
dc.date2015-11-27T12:18:35Z
dc.date2015-11-27T12:18:35Z
dc.date.accessioned2018-03-29T00:51:29Z
dc.date.available2018-03-29T00:51:29Z
dc.identifierInternational Journal Of Clinical Pharmacology And Therapeutics. v. 33, n. 1, p. 27-31, 1995-Jan.
dc.identifier0946-1965
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/7711987
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193832
dc.identifier7711987
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294065
dc.descriptionThe bioavailability of two tablet formulations of cetirizine (Zetir from Abbott and Zyrtek from UCB) were compared in 14 healthy male volunteers who received a single dose of 10 mg of cetirizine dihydrochloride in an open randomized two-period crossover design with a 7-day washout period between doses. Plasma samples were obtained over a 24 h interval and cetirizine concentrations were determined by HPLC with ultraviolet detection. From the plasma cetirizine concentration vs. time curves, AUC(0-24) (area under the concentration vs. time curves from 0 to 24 h), Cmax (maximum achieved concentration), Tmax (time to achieve Cmax), Ke (terminal first order elimination constant), elimination half-life (t1/2) and AUC(0-infinity) (area under the concentration vs. time curves extrapolated to infinity) were obtained. The two cetirizine dihydrochloride tablet brands did not show statistically significant differences in bioavailability as assessed by analysis of AUC(0-24), AUC(0-infinity), Cmax, Tmax, Ke and t1/2 values. Based on these results and on the U.S. Food and Drug Administration requirements [1985, 1993], we conclude that both formulations are bioequivalent.
dc.description33
dc.description27-31
dc.languageeng
dc.relationInternational Journal Of Clinical Pharmacology And Therapeutics
dc.relationInt J Clin Pharmacol Ther
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectBiological Availability
dc.subjectCetirizine
dc.subjectChemistry, Pharmaceutical
dc.subjectChromatography, High Pressure Liquid
dc.subjectDrug Administration Schedule
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectTablets
dc.titleComparative Bioavailability Of Single Doses Of Tablet Formulations Of Cetirizine Dihydrochloride In Healthy Male Volunteers.
dc.typeArtículos de revistas


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