Dissimilarity Between Prostaglandin E1 And Nitric Oxide Donors As Potentiators Of Plasma Exudation In The Rabbit Skin In Vivo.

dc.creatorMariani-Pedroso, S R
dc.creatorBizeto, L
dc.creatorAntunes, E
dc.creatorZatz, R
dc.creatorde Nucci, G
dc.date1995-Jun
dc.date2015-11-27T12:18:34Z
dc.date2015-11-27T12:18:34Z
dc.date.accessioned2018-03-29T00:51:27Z
dc.date.available2018-03-29T00:51:27Z
dc.identifierProstaglandins, Leukotrienes, And Essential Fatty Acids. v. 52, n. 6, p. 399-402, 1995-Jun.
dc.identifier0952-3278
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/7644562
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193824
dc.identifier7644562
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294057
dc.descriptionThe ability of prostaglandin E1 (PGE1) and nitric oxide (NO) donor compounds such as sodium nitroprusside (SNP), glyceryl trinitrate (GTN), and 3-morpholino-sydnonimine (SIN-1) to modulate the histamine- and bradykinin-induced increase in microvascular permeability have been investigated in rabbit skin. The effect of the NO synthesis inhibitor N omega-nitro-L-arginine methyl ester (L-NAME) on the plasma exudation induced by histamine and bradykinin was also studied. Local edema formation was evaluated using [125I]human serum albumin. New Zealand white rabbits received an intravenous injection of [125I]human albumin followed immediately by the intradermal injection of edematogenic agents into the shaved dorsolateral skin. PGE1 (0.1 nmol/site) significantly potentiated both histamine- and bradykinin-induced edema. In contrast, SNP (0.4-400 nmol/site), SIN-1 (0.4-400 nmol/site), and GTN (0.4-40 nmol/site) did not affect the edematogenic response induced by either histamine or bradykinin. GTN (0.4-40 nmol/site) also had no effect on the increase in plasma exudation induced by histamine and bradykinin in the presence of PGE1. L-NAME (50-400 nmol/site, but not its enantiomer D-NAME, dose-dependently reduced the edema formation induced by a combination of either histamine or bradykinin with PGE1. This inhibition was significantly reversed by SNP (4-400 nmol/site) and by high doses (2.5 mumol/site) of L-arginine (but not by D-arginine). Our results thus demonstrate that PGE1, but not nitrovasodilators, can actually potentiate histamine- and bradykinin-induced edema in rabbit skin.(ABSTRACT TRUNCATED AT 250 WORDS)
dc.description52
dc.description399-402
dc.languageeng
dc.relationProstaglandins, Leukotrienes, And Essential Fatty Acids
dc.relationProstaglandins Leukot. Essent. Fatty Acids
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAlprostadil
dc.subjectAnimals
dc.subjectArginine
dc.subjectBradykinin
dc.subjectCapillary Permeability
dc.subjectEdema
dc.subjectExudates And Transudates
dc.subjectHistamine
dc.subjectHistamine Antagonists
dc.subjectMale
dc.subjectMolsidomine
dc.subjectNg-nitroarginine Methyl Ester
dc.subjectNitric Oxide
dc.subjectNitroglycerin
dc.subjectNitroprusside
dc.subjectRabbits
dc.subjectSkin
dc.subjectVasodilator Agents
dc.titleDissimilarity Between Prostaglandin E1 And Nitric Oxide Donors As Potentiators Of Plasma Exudation In The Rabbit Skin In Vivo.
dc.typeArtículos de revistas


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