Effects Of Escapable And Inescapable Foot-shock On Rat Atrial Beta-adrenoceptors.

dc.creatorBassani, R A
dc.creatorBassani, J W
dc.date1993-Apr
dc.date2015-11-27T12:18:24Z
dc.date2015-11-27T12:18:24Z
dc.date.accessioned2018-03-29T00:51:05Z
dc.date.available2018-03-29T00:51:05Z
dc.identifierPharmacology, Biochemistry, And Behavior. v. 44, n. 4, p. 869-75, 1993-Apr.
dc.identifier0091-3057
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/8385784
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193733
dc.identifier8385784
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293966
dc.descriptionThe chronotropic responsiveness to norepinephrine (NE) and isoproterenol (ISO) was determined in right atria isolated from rats submitted to repeated escapable or inescapable foot-shock. Significant postjunctional supersensitivity to ISO, but not to NE, was observed in both groups. No significant change in the pA2 value of metoprolol (a selective beta 1-adrenoceptor antagonist) was detected. However, a decrease of the maximum response to soterenol, a partial agonist at beta 1-adrenoceptors, occurred only after inescapable foot-shock. The enhanced sensitivity to ISO was abolished by butoxamine (a selective beta 2-adrenoceptor antagonist) and accompanied by a marked increase in the pA2 value of this antagonist. We conclude that the ability to control the shock prevented the down-regulation of the pacemaker beta 1-adrenoceptors but not the increased participation of beta 2-adrenoceptors in the response of the rat sinoatrial node to catecholamines after repeated foot-shock.
dc.description44
dc.description869-75
dc.languageeng
dc.relationPharmacology, Biochemistry, And Behavior
dc.relationPharmacol. Biochem. Behav.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectButoxamine
dc.subjectElectroshock
dc.subjectEthanolamines
dc.subjectHeart Atria
dc.subjectHeart Rate
dc.subjectIsoproterenol
dc.subjectMale
dc.subjectMetoprolol
dc.subjectMyocardium
dc.subjectNorepinephrine
dc.subjectOxidopamine
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Adrenergic, Beta
dc.subjectStress, Psychological
dc.subjectSympathectomy, Chemical
dc.titleEffects Of Escapable And Inescapable Foot-shock On Rat Atrial Beta-adrenoceptors.
dc.typeArtículos de revistas


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