Anti-inflammatory Activities Of Ph Cl28a In Rats In Vivo.

dc.creatorSantana, A C
dc.creatorHyslop, S
dc.creatorAntunes, E
dc.creatorDe Nucci, G
dc.creatorBakhle, Y S
dc.date1993-Feb
dc.date2015-11-27T12:18:24Z
dc.date2015-11-27T12:18:24Z
dc.date.accessioned2018-03-29T00:51:05Z
dc.date.available2018-03-29T00:51:05Z
dc.identifierEuropean Journal Of Pharmacology. v. 231, n. 2, p. 237-42, 1993-Feb.
dc.identifier0014-2999
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/8384113
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193732
dc.identifier8384113
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293965
dc.descriptionThe anti-inflammatory effects of Ph CL28A, a potentiator of prostacyclin output and inhibitor of leukotriene (LT) synthesis, were assessed in two models of acute inflammation. In paw oedema induced by carrageenan in rats, Ph CL28A (10-100 mg/kg), given i.p. at the same time as the carrageenan, inhibited oedema for up to 4 h. When indomethacin or Ph CL28A was given locally into the paw with carrageenan, indomethacin inhibited oedema formation but Ph CL28A potentiated the oedema for up to 4 h. As Ph CL28A does not inhibit cyclo-oxygenase, its anti-inflammatory effects in this model may reflect its ability to increase prostacyclin output. In pleurisy induced by carrageenan in rats, there were increases in leukocytes, LTB4, thromboxane B2 (TxB2) and 6-oxo-prostaglandin F1 alpha (6-oxo-PGF1 alpha) in the pleural fluid over 3 h. In this model, Ph CL28A (30 mg/kg) given i.p. decreased leukocyte numbers and LTB4 but did not affect TxB2 or 6-oxo-PGF1 alpha. Indomethacin decreased both prostanoids but did not affect leukocyte accumulation. The beneficial effects of Ph CL28A in two different models of acute inflammation suggests that it may have potential as an anti-inflammatory agent.
dc.description231
dc.description237-42
dc.languageeng
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subject6-ketoprostaglandin F1 Alpha
dc.subjectAnimals
dc.subjectAnti-inflammatory Agents, Non-steroidal
dc.subjectAzo Compounds
dc.subjectBlood Pressure
dc.subjectCarrageenan
dc.subjectEdema
dc.subjectEpoprostenol
dc.subjectHydroxyprostaglandin Dehydrogenases
dc.subjectIndomethacin
dc.subjectLeukotriene B4
dc.subjectMale
dc.subjectPleurisy
dc.subjectRadioimmunoassay
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectThromboxane B2
dc.titleAnti-inflammatory Activities Of Ph Cl28a In Rats In Vivo.
dc.typeArtículos de revistas


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