Comparison Of The Antiviral Activity And Toxicity Of A Protein Magnesium Ammonium Phospholinoleate Anhydride Polymer With Other Antiviral Drugs.

dc.creatorDurán, N
dc.creatorHaun, M
dc.creatorPereira-da-Silva, L
dc.creatorPisani, R
dc.creatorPisani, F J
dc.creatorSouza-Brito, A R
dc.creatorMazetto, M N
dc.creatorDa-Silva-Nunes, O
dc.date1990
dc.date2015-11-27T12:18:20Z
dc.date2015-11-27T12:18:20Z
dc.date.accessioned2018-03-29T00:50:58Z
dc.date.available2018-03-29T00:50:58Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 23, n. 12, p. 1303-13, 1990.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/2136564
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193707
dc.identifier2136564
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293940
dc.description1. SB-73, a magnesium ammonium phospholinoleate anhydride aggregate, exhibited antiviral action in vitro in the concentration range of 50 to 100 micrograms/ml against herpes simplex type 1, stomatitis vesicular virus, adenovirus type 5, and in vivo in the dose range of 0.7 to 1.3 mg/kg against canine parvovirus and distemper virus. 2. The lethal dose (LD50) was 2.71 +/- 1.55 g/kg body weight in mice inoculated intraperitoneally. Oral ingestion of the aggregate up to 30 g/kg body weight by mice had no lethal effects during the 14 days of observation. 3. In in vitro cytotoxicity experiments with fibroblasts (V-79 Chinese hamster cell line), no toxic effects were observed with SB-73 concentrations (120 micrograms/ml) having antiviral activity. 4. In a cellular proliferation experiment using hamster V-79 cells, we observed 72% proliferation after treatment of the cells with a high concentration (500 micrograms/ml) of SB-73. 5. Compound SB-73 showed no genotoxicity for human lymphocytes at concentrations of 100 micrograms/ml. 6. When the cytotoxicity and genotoxicity of SB-73 were compared with those of acyclovir, idoxuridine and AZT at 500 micrograms/ml concentrations the compound was found to have effects similar to those of acyclovir.
dc.description23
dc.description1303-13
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAcyclovir
dc.subjectAnimals
dc.subjectAntiviral Agents
dc.subjectChromosome Aberrations
dc.subjectFemale
dc.subjectHumans
dc.subjectIdoxuridine
dc.subjectLethal Dose 50
dc.subjectLinoleic Acids
dc.subjectMagnesium
dc.subjectMale
dc.subjectMice
dc.subjectMitotic Index
dc.subjectOrganophosphorus Compounds
dc.subjectPolymers
dc.subjectViruses
dc.subjectZidovudine
dc.titleComparison Of The Antiviral Activity And Toxicity Of A Protein Magnesium Ammonium Phospholinoleate Anhydride Polymer With Other Antiviral Drugs.
dc.typeArtículos de revistas


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