Effects Of Phoneutria Nigriventer Venom On Rabbit Vascular Smooth Muscle.

dc.creatorAntunes, E
dc.creatorMarangoni, R A
dc.creatorBorges, N C
dc.creatorHyslop, S
dc.creatorFontana, M D
dc.creatorde-Nucci, G
dc.date1993
dc.date2015-11-27T12:18:19Z
dc.date2015-11-27T12:18:19Z
dc.date.accessioned2018-03-29T00:50:57Z
dc.date.available2018-03-29T00:50:57Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 26, n. 1, p. 81-91, 1993.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/8220272
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193700
dc.identifier8220272
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293933
dc.description1. The effects of Phneutria nigriventer venom (PNV) on rabbit vascular smooth muscle have been investigated. De-endothelialized vascular strips were superfused in a cascade system with oxygenated (95% O2 + 5% CO2) Krebs solution at 37 degrees C. 2. Phoneutria nigriventer venom (0.3-30 micrograms) produced dose-dependent and short-lived contractions of both venous (cava, mesenteric and jugular veins) and arterial (pulmonary and mesenteric arteries) tissues. 3. Methysergide (5.0 microM) did not significantly affect PNV-induced contractions in venous tissues (cava and mesenteric veins) or pulmonary artery, indicating that serotonin is not involved in the contraction. This was confirmed when PNV was dialyzed (24-48 h) since the contracting activity was still observed on the above tissues. In addition, the spasmogenic activity induced by dialyzed PNV was greatly reduced by incubating the venom with trypsin. 4. Neither tetrodotoxin (3.0 microM) nor phenoxybenzamine (0.05 microM) significantly affected PNV-induced contractions, suggesting that voltage-dependent sodium channel activation or endogenous catecholamine release from autonomic nerve endings on the vascular walls do not play a role in the response to PNV. 5. Our results demonstrate that PNV contains non-dialyzable components, probably peptides, that are responsible for the contractile activity on rabbit veins and pulmonary artery strips.
dc.description26
dc.description81-91
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectGuinea Pigs
dc.subjectMale
dc.subjectMuscle, Smooth, Vascular
dc.subjectRabbits
dc.subjectSpider Venoms
dc.subjectTime Factors
dc.subjectTrypsin
dc.titleEffects Of Phoneutria Nigriventer Venom On Rabbit Vascular Smooth Muscle.
dc.typeArtículos de revistas


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