Reversal Of Learned Helplessness By Chronic Lithium Treatment At A Prophylactic Level.

dc.creatorFaria, M S
dc.creatorTeixeira, N A
dc.date1993-Nov
dc.date2015-11-27T12:18:17Z
dc.date2015-11-27T12:18:17Z
dc.date.accessioned2018-03-29T00:50:55Z
dc.date.available2018-03-29T00:50:55Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 26, n. 11, p. 1201-12, 1993-Nov.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/8136720
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193690
dc.identifier8136720
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293923
dc.description1. The effect of chronic lithium (Li) administration in a learned helplessness (LH) model was investigated. Female Wistar rats (190-210 g) received either tap water ad libitum (N = 56) or 20 mM LiCl (N = 63) in the drinking water or were water restricted (35% based on lower liquid intake of rats receiving lithium, N = 40) for 30 days. On the 28th day, each of these groups was divided into three subgroups which received escapable (ES), inescapable (IS) or no shock (NS) treatment in shuttle boxes. All groups were submitted to the escape test on the 29th day and sacrificed on the 30th day, when blood samples were taken for measurement of serum lithium, sodium and potassium concentrations. 2. The NS group had lower serum Li levels (0.36 +/- 0.06, N = 15) than the ES (0.46 +/- 0.07, N = 15) or IS group (0.44 +/- 0.09, N = 25). The Li-pretreated group subjected to IS had a more effective escape performance than the IS group under water restriction and showed the same behaviour as animals not submitted to shocks. 3. We conclude that chronic treatment with Li at a serum level of 0.44 +/- 0.09 mEq/l prevents learned helplessness in rats. These results corroborate the validity of the use of this model for the assessment of the capacity of Li to protect against some depressive episodes.
dc.description26
dc.description1201-12
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectDepression
dc.subjectFemale
dc.subjectHelplessness, Learned
dc.subjectLithium
dc.subjectLithium Chloride
dc.subjectMultivariate Analysis
dc.subjectPotassium
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSodium
dc.subjectTime Factors
dc.titleReversal Of Learned Helplessness By Chronic Lithium Treatment At A Prophylactic Level.
dc.typeArtículos de revistas


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