Opioid Nature Of Learned Helplessness And Stress Induced Analgesia Observed Without Re-exposure To Shock.

dc.creatorHunziker, M.H.L.
dc.date1992-Apr
dc.date2015-11-27T12:18:15Z
dc.date2015-11-27T12:18:15Z
dc.date.accessioned2018-03-29T00:50:50Z
dc.date.available2018-03-29T00:50:50Z
dc.identifierBehavioural Pharmacology. v. 3, n. 2, p. 117-121, 1992-Apr.
dc.identifier1473-5849
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11224108
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193671
dc.identifier11224108
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293904
dc.descriptionIt has been shown that uncontrollable shocks that produce learned helplessness also produce long-term opioid analgesia if th animal is re-exposed to shock immediately before the test. The present study was conducted in order to investigate if this effect can be observed 24h after the uncontrollable shock treatment without re-exposure to shock, and if it is opioid mediated. Long-term analgesia was found in the absence of re-exposure to shock, and was prevented by an i.p. injection of naloxone (10mg/kg) administered 10min before the test. The learned helplessness effect produced by the same shock treatment was prevented by the administration of 10 and 20mg/kg of naloxone 10min before the shuttlebox test, but not by a lower naloxone dose (5mg/kg). These findings suggest that the shock re-exposure requirement proposed in previous studies is not crucial in determining the long-term analgesia, and that both the long-term analgesia and the learned helplessness effect produced by this shock treatment were opioid mediated.
dc.description3
dc.description117-121
dc.languageeng
dc.relationBehavioural Pharmacology
dc.relationBehav Pharmacol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.titleOpioid Nature Of Learned Helplessness And Stress Induced Analgesia Observed Without Re-exposure To Shock.
dc.typeArtículos de revistas


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