Protective Effect Of Trifluoperazine On The Mitochondrial Damage Induced By Ca2+ Plus Prooxidants.

dc.creatorPereira, R S
dc.creatorBertocchi, A P
dc.creatorVercesi, A E
dc.date1992-Nov
dc.date2015-11-27T12:18:12Z
dc.date2015-11-27T12:18:12Z
dc.date.accessioned2018-03-29T00:50:47Z
dc.date.available2018-03-29T00:50:47Z
dc.identifierBiochemical Pharmacology. v. 44, n. 9, p. 1795-801, 1992-Nov.
dc.identifier0006-2952
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/1449534
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193654
dc.identifier1449534
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293887
dc.descriptionIsolated rat liver mitochondria undergo extensive swelling and disruption of membrane potential when they accumulate Ca2+ in the presence of a prooxidant such as diamide or t-butylhydroperoxide. The phenothiazinic drug trifluoperazine, at concentrations (15-35 microM) which do not inhibit respiration or the influx of Ca2+ into mitochondria, significantly protected mitochondria against the deleterious effects of Ca2+ plus a prooxidant. In contrast, at concentrations higher than 100 microM the drug potentiated these deleterious effects of Ca2+ and prooxidants and had a damaging effect per se on the inner mitochondrial membrane. It is proposed that the protection conferred by the drug is mediated by changes in membrane protein structure that decrease the production of protein thiol cross-linkings which occur when mitochondria accumulate calcium under oxidant stress conditions.
dc.description44
dc.description1795-801
dc.languageeng
dc.relationBiochemical Pharmacology
dc.relationBiochem. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCalcium
dc.subjectCell Membrane Permeability
dc.subjectIntracellular Membranes
dc.subjectKinetics
dc.subjectMembrane Potentials
dc.subjectMembrane Proteins
dc.subjectMitochondria, Liver
dc.subjectMitochondrial Swelling
dc.subjectOxidants
dc.subjectOxygen Consumption
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSuccinates
dc.subjectSulfhydryl Compounds
dc.subjectTrifluoperazine
dc.titleProtective Effect Of Trifluoperazine On The Mitochondrial Damage Induced By Ca2+ Plus Prooxidants.
dc.typeArtículos de revistas


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