Effects Of Injection Of Selective Adrenergic Receptor Antagonists Into The Lateral Hypothalamic Area On Renal Function.

dc.creatorGontijo, J A
dc.creatorSilva-Netto, C R
dc.creatorFurtado, M R
dc.date1990
dc.date2015-11-27T12:18:08Z
dc.date2015-11-27T12:18:08Z
dc.date.accessioned2018-03-29T00:50:42Z
dc.date.available2018-03-29T00:50:42Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 23, n. 11, p. 1205-8, 1990.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/1983458
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193634
dc.identifier1983458
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293867
dc.descriptionStudies were undertaken to characterize the participation of specific alpha-1,alpha-2 and beta adrenoceptors of the lateral hypothalamic area (LHA) in the urinary excretion of sodium and potassium. Alpha-1 and alpha-2 LHA receptors were shown to participate in the regulation of renal sodium and potassium excretion. The effects of noradrenaline microinjection (30 nmol in 1 microliter) into the LHA on urinary sodium excretion (UNaV) are blocked by previous injection of the alpha-1 antagonist prazosin (4 nmol in 1 microliter) from 3.22 +/- 0.25 to 0.59 +/- 0.04 microEq min-1 100 g body weight-1. Pre-injection of yohimbine, an alpha-2 antagonist (4 nmol in 1 microliter), synergistically potentiated the action of noradrenaline on UNaV (3.22 +/- 0.25 to 4.02 +/- 0.27 microEq min-1 100 g body weight-1) and on urinary potassium excretion (UKV) (0.70 +/- 0.08 to 1.15 +/- 0.12 microEq min-1 100 g body weight-1). The beta-adrenergic blockers metoprolol (100 nmol in 1 microliter) and propranolol (100 nmol in 1 microliter) had no synergistic or antagonistic action on the sodium excretion fraction, suggesting that neither of these receptors is present in LHA. Our results indicate that natriuresis occurs even in the absence of changes in glomerular filtration rate and demonstrate an inhibitory natriuretic effect of an alpha-1 blocker (prazosin) injected into the LHA before adrenaline, while an alpha-2 antagonist (yohimbine) yielded a potentiating effect.
dc.description23
dc.description1205-8
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdrenergic Alpha-antagonists
dc.subjectAdrenergic Beta-antagonists
dc.subjectAnimals
dc.subjectHypothalamic Area, Lateral
dc.subjectMale
dc.subjectPotassium
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSodium
dc.titleEffects Of Injection Of Selective Adrenergic Receptor Antagonists Into The Lateral Hypothalamic Area On Renal Function.
dc.typeArtículos de revistas


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