Sex-related Canatoxin-induced Blood Glucose Alterations In The Rat.

dc.creatorPires-Barbosa, R
dc.creatorRibeiro-DaSilva, G
dc.date1989
dc.date2015-11-27T12:10:06Z
dc.date2015-11-27T12:10:06Z
dc.date.accessioned2018-03-29T00:50:40Z
dc.date.available2018-03-29T00:50:40Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 22, n. 12, p. 1507-13, 1989.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/2641357
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193624
dc.identifier2641357
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293857
dc.description1. The present study was designed to characterize sex-related canatoxin-induced blood glucose alterations in rats. 2. Chronic administration of canatoxin (50 mU, ip, daily for 3 days) induced hypoglycemia in female rats (N = 6) (-36.54 +/- 3.24%, P less than 0.05). The response of pregnant rats (N = 8) was similar to that observed for male rats (+29.57 +/- 4.70%). 3. Administration of canatoxin did not modify blood glucose levels of gonadectomized male or female rats. Similarly, pretreatment of intact male or female rats with human chorionic gonadotropin (40 IU/kg, im) blocked the effect of canatoxin on blood glucose levels. 4. Gonadal steroid replacement (testosterone, 10 mg/kg, im) for gonadectomized male rats did not reverse the inhibition of canatoxin-induced blood glucose alterations, whereas pretreatment of intact female rats (N = 6) with testosterone (10 mg/kg, im) significantly attenuated the canatoxin-induced hypoglycemia. 5. These data indicate that the blood glucose alterations produced by canatoxin in rats are under hormonal regulation.
dc.description22
dc.description1507-13
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBlood Glucose
dc.subjectCastration
dc.subjectFemale
dc.subjectLectins
dc.subjectLethal Dose 50
dc.subjectMale
dc.subjectPlant Proteins
dc.subjectPregnancy
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSex Characteristics
dc.subjectToxins, Biological
dc.titleSex-related Canatoxin-induced Blood Glucose Alterations In The Rat.
dc.typeArtículos de revistas


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