Responsiveness To Epinephrine In Adult Spontaneously Hypertensive Rat Tail Artery: Preferential Mediation By Postjunctional Alpha 2-adrenoceptors.

dc.creatorde Moraes, S
dc.creatorBento, A C
dc.creatorde Lima, W T
dc.date1988-Apr
dc.date2015-11-27T12:09:59Z
dc.date2015-11-27T12:09:59Z
dc.date.accessioned2018-03-29T00:50:30Z
dc.date.available2018-03-29T00:50:30Z
dc.identifierJournal Of Cardiovascular Pharmacology. v. 11, n. 4, p. 473-7, 1988-Apr.
dc.identifier0160-2446
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/2453752
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193584
dc.identifier2453752
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293817
dc.descriptionWe studied the role played by postjunctional adrenoceptors in the vasoconstrictor responses of perfused tail arteries of young prehypertensive (4-6 weeks old) and adult (14-16 weeks) spontaneously hypertensive rats (SHR) with norepinephrine (NE), phenylephrine and epinephrine. Age-matched Wistar normotensive rats (WNR) were also used. In tail artery of young SHR, as well as in age-matched WNR and adult WNR, responsiveness to the vasoconstrictor agents did not differ. Determination of KB values of prazosin using phenylephrine and epinephrine as agonists and analysis of Schild plots indicate that responsiveness to the vasoconstrictor agents in young SHR tail artery is mediated by alpha 1-adrenoceptors. Tail arteries of adult SHR were more responsive to epinephrine than were tail arteries of age-matched WNR. In tail arteries of adult SHR, the KB value of prazosin against epinephrine remains undetermined since the slope of the Schild plot statistically differs from 1.0 (0.32). These results strongly suggest that in perfused tail arteries of adult SHR, responses to epinephrine are also mediated by alpha 2-adrenoceptors. We postulate an important but unknown role for the interaction between epinephrine and postjunctional alpha 2-adrenoceptors in the development and maintenance of genetically-induced hypertension.
dc.description11
dc.description473-7
dc.languageeng
dc.relationJournal Of Cardiovascular Pharmacology
dc.relationJ. Cardiovasc. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectArteries
dc.subjectEpinephrine
dc.subjectHypertension
dc.subjectMale
dc.subjectNorepinephrine
dc.subjectPhenylephrine
dc.subjectRats
dc.subjectRats, Inbred Shr
dc.subjectRats, Inbred Wky
dc.subjectReceptors, Adrenergic, Alpha
dc.subjectTail
dc.subjectVasoconstriction
dc.titleResponsiveness To Epinephrine In Adult Spontaneously Hypertensive Rat Tail Artery: Preferential Mediation By Postjunctional Alpha 2-adrenoceptors.
dc.typeArtículos de revistas


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