Importance of anesthesia for the genesis of neurogenic pulmonary edema in spinal cord injury

dc.creatorFilho, MBL
dc.creatorMorandin, RC
dc.creatorde Almeida, AR
dc.creatorCambiucci, EC
dc.creatorBorges, G
dc.creatorGontijo, JAR
dc.creatorMetze, K
dc.date2005
dc.date40179
dc.date2014-11-13T16:36:08Z
dc.date2015-11-26T18:08:16Z
dc.date2014-11-13T16:36:08Z
dc.date2015-11-26T18:08:16Z
dc.date.accessioned2018-03-29T00:50:21Z
dc.date.available2018-03-29T00:50:21Z
dc.identifierNeuroscience Letters. Elsevier Ireland Ltd, v. 373, n. 2, n. 165, n. 170, 2005.
dc.identifier0304-3940
dc.identifier1872-7972
dc.identifierWOS:000225811200017
dc.identifier10.1016/j.neulet.2004.10.019
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70057
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70057
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70057
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293779
dc.descriptionThere are reports describing both provocation and inhibition of neurogenic pulmonary edema by anesthetic drugs. Therefore, we compared the effect of two types of anesthesia on the formation of neurogenic pulmonary edema in rats with balloon-induced acute spinal cord injury. Animals with sham procedure (group 1) were anesthesized by intraperitoneal sodium pentobarbital. In the experimental groups. rats were submitted 10 acute spinal cord lesion by insufflations of a balloon in the epidural space at TS for 1 min (group 3 under i.p. sodium pentobarbital and group 2 under i.p. xylazine-ketamine anesthesia). In rats with pentobarbital anesthesia, systolic blood pressure doubled the baseline value during compression. whereas this effect was less pronounced in the ketamine-xylazine group. The pulmonary index (100 x wet lung weight/body weight) was 0.395 (+/-0.018) in sham-operated rats, rose to 0.1199 (+/-0.060) in group 2, and was maximum under pentobarbital anesthesia (0.639 +/- 0.14: p = 0.0018). Histologic examination of the spinal cord showed parenchymal ruptures and acute hemorrhage. Comparison of the pulmonary index with histologic slides of lung parenchyma revealed that relevant intra-alveolar edema occurred only for index values above 0.55. On electron microscopy, endothelial alterations, and damage of the alveolar lining cells were found. Our study indicates that neurogenic pulmonary edema caused by spinal cord injury is less pronounced in rats under xylazine-ketamine anesthesia, when compared with pentobarbital. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
dc.description373
dc.description2
dc.description165
dc.description170
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationNeuroscience Letters
dc.relationNeurosci. Lett.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectspinal cord injury
dc.subjectneurogenic pulmonary edema
dc.subjectpentobarbital
dc.subjectxylazine
dc.subjectketamine
dc.subjectNeuropeptide-y
dc.subjectRespiratory Complications
dc.subjectAcute Compression
dc.subjectBlood-pressure
dc.subjectRats
dc.subjectKetamine
dc.subjectInhibition
dc.subjectExpression
dc.subjectExperience
dc.subjectDisease
dc.titleImportance of anesthesia for the genesis of neurogenic pulmonary edema in spinal cord injury
dc.typeArtículos de revistas


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