Presence of Myofibroblasts and Expression of Matrix Metalloproteinase-2 (MMP-2) in Ameloblastomas Correlate with Rupture of the Osseous Cortical

dc.creatorFregnani, ER
dc.creatorSobral, LM
dc.creatorAlves, FA
dc.creatorSoares, FA
dc.creatorKowalski, LP
dc.creatorColetta, RD
dc.date2009
dc.dateJUN
dc.date2014-11-13T11:49:07Z
dc.date2015-11-26T18:07:09Z
dc.date2014-11-13T11:49:07Z
dc.date2015-11-26T18:07:09Z
dc.date.accessioned2018-03-29T00:49:16Z
dc.date.available2018-03-29T00:49:16Z
dc.identifierPathology & Oncology Research. Springer, v. 15, n. 2, n. 231, n. 240, 2009.
dc.identifier1219-4956
dc.identifierWOS:000266091600011
dc.identifier10.1007/s12253-008-9110-4
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70160
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70160
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70160
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293518
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionMyofibroblasts are frequent in the stroma of neoplasm and by the expression of proteinases they can influence tumor infiltration and progression. In the present study, presence of myofibroblasts and expression of matrix metalloproteinase-2 (MMP-2) and urokinase plasminogen activator (uPA) were examined in intra-osseous solid multicystic ameloblastomas to determine their roles in the clinicopathological features of the tumors. Fifty seven ameloblastomas were analyzed immunohistochemically with antibodies against the isoform alpha of the smooth muscle actin (alpha-SMA), a specific marker of myofibroblasts, MMP-2 and uPA. Myofibroblasts were found in the stroma, in close contact with neoplastic cell islands, of similar to 58% (n = 33) of the ameloblastomas. MMP-2 and uPA were found in the cytoplasm of both neoplastic and stromal cells. A significant correlation between presence of myofibroblasts and MMP-2 expression was observed. Abundant presence of myofibroblast in the stroma of the tumors and expression of MMP-2 in the neoplastic or stromal cells were significantly correlated with rupture of the osseous cortical, which has been considered an important prognostic marker of ameloblastoma aggressiveness. Ours results suggest that abundant presence of myofibroblasts and expression of MMP-2 in solid ameloblastomas may be associated with a more aggressive infiltrative behavior.
dc.description15
dc.description2
dc.description231
dc.description240
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherSpringer
dc.publisherDordrecht
dc.publisherHolanda
dc.relationPathology & Oncology Research
dc.relationPathol. Oncol. Res.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectAmeloblastoma
dc.subjectMatrix metalloproteinase-2
dc.subjectMyofibroblast
dc.subjectPrognosis
dc.subjectUrokinase plasminogen activator
dc.subjectUrokinase Plasminogen-activator
dc.subjectImmunohistochemical Detection
dc.subjectStromal Cells
dc.subjectIntestinal Myofibroblasts
dc.subjectHepatocellular-carcinoma
dc.subjectOdontogenic Cysts
dc.subjectIn-situ
dc.subjectTumor
dc.subjectDifferentiation
dc.subjectCancer
dc.titlePresence of Myofibroblasts and Expression of Matrix Metalloproteinase-2 (MMP-2) in Ameloblastomas Correlate with Rupture of the Osseous Cortical
dc.typeArtículos de revistas


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