dc.creatorVassallo, J
dc.creatorBousquet, M
dc.creatorQuelen, C
dc.creatorAl Saati, T
dc.creatorDelsol, G
dc.creatorBrousset, P
dc.date2007
dc.dateMAY
dc.date2014-11-19T22:11:42Z
dc.date2015-11-26T18:06:40Z
dc.date2014-11-19T22:11:42Z
dc.date2015-11-26T18:06:40Z
dc.date.accessioned2018-03-29T00:48:51Z
dc.date.available2018-03-29T00:48:51Z
dc.identifierJournal Of Clinical Pathology. B M J Publishing Group, v. 60, n. 5, n. 573, n. 575, 2007.
dc.identifier0021-9746
dc.identifierWOS:000246594100026
dc.identifier10.1136/jcp.2005.032896
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78541
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/78541
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78541
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293412
dc.descriptionFollicular lymphoma (FL) is a neoplasm originating from germinal centre cells, corresponding to 25-40% of non-Hodgkin's lymphomas. Transformation into diffuse large B cell lymphoma (DLBCL) occurs in about one-third of cases. CD5 is expressed in B-chronic lymphoid leukaemia/small lymphocytic lymphoma and mantle cell lymphoma, but can rarely be expressed in conjunction with CD10 in well-documented cases of FL. In this report one case of grade 1 FL is described, which transformed into a DLBCL 6 months after initial diagnosis, with both tumours expressing CD5. In both specimens, neoplastic cells were strongly positive for CD20, CD79a, bcl-2, bcl-6 and CD5 in virtually all cells. CD10 was strongly positive in initial specimens and weakly positive in the DLBCL. Investigation using the PCR confirmed the derivation of the DLBCL from the FL as they presented the same immunoglobulin heavy chain gene rearrangement and the same BCL2-J(H) break point.
dc.description60
dc.description5
dc.description573
dc.description575
dc.languageen
dc.publisherB M J Publishing Group
dc.publisherLondon
dc.publisherInglaterra
dc.relationJournal Of Clinical Pathology
dc.relationJ. Clin. Pathol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectCd10
dc.subjectClassification
dc.subjectCoexpression
dc.subjectDiagnosis
dc.subjectNeoplasms
dc.subjectT(14/18)
dc.subjectSubset
dc.subjectCd5
dc.titleCD5-positive diffuse large B cell lymphoma arising from a CD5-positive follicular lymphoma
dc.typeArtículos de revistas


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