| dc.creator | Macedo, OFL | |
| dc.creator | Andrade, GRS | |
| dc.creator | Conegero, LS | |
| dc.creator | Barreto, LS | |
| dc.creator | Costa, NB | |
| dc.creator | Gimenez, IF | |
| dc.creator | Almeida, LE | |
| dc.creator | Kubota, D | |
| dc.date | 2012 | |
| dc.date | FEB | |
| dc.date | 2014-07-30T14:32:06Z | |
| dc.date | 2015-11-26T18:06:10Z | |
| dc.date | 2014-07-30T14:32:06Z | |
| dc.date | 2015-11-26T18:06:10Z | |
| dc.date.accessioned | 2018-03-29T00:48:22Z | |
| dc.date.available | 2018-03-29T00:48:22Z | |
| dc.identifier | Spectrochimica Acta Part A-molecular And Biomolecular Spectroscopy. Pergamon-elsevier Science Ltd, v. 86, n. 101, n. 106, 2012. | |
| dc.identifier | 1386-1425 | |
| dc.identifier | WOS:000300515500017 | |
| dc.identifier | 10.1016/j.saa.2011.10.010 | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59807 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/59807 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1293294 | |
| dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Here we report the preparation of a trimethoprim/2-hydroxypropyl-gamma-cyclodextrin inclusion complex along with a physicochemical study, structural characterization, and molecular modeling of the complex. As main results, we observed from phase-solubility studies at two temperatures (20 degrees C and 35 degrees C) that the association constants decrease with increasing temperature. Values for K-1:1 constant were of the same magnitude order of those found for the parent gamma-CD. The inclusion orientation as evidenced by ROESY measurements involves the inclusion of the 3.45-trimethoxybenzyl ring in the CD cavity from the larger rim. This is in agreement with semiempirical molecular modeling calculation. (C) 2011 Elsevier B.V. All rights reserved. | |
| dc.description | 86 | |
| dc.description | 101 | |
| dc.description | 106 | |
| dc.description | Finep | |
| dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Fapitec | |
| dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.language | en | |
| dc.publisher | Pergamon-elsevier Science Ltd | |
| dc.publisher | Oxford | |
| dc.publisher | Inglaterra | |
| dc.relation | Spectrochimica Acta Part A-molecular And Biomolecular Spectroscopy | |
| dc.relation | Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. | |
| dc.rights | fechado | |
| dc.rights | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
| dc.source | Web of Science | |
| dc.subject | Trimethoprim | |
| dc.subject | 2-Hydroxypropyl-gamma-cyclodextrin | |
| dc.subject | Inclusion complex | |
| dc.subject | Phase-solubility diagram | |
| dc.subject | Molecular modeling | |
| dc.subject | Beta-cyclodextrin | |
| dc.subject | Semiempirical Methods | |
| dc.subject | Trimethoprim | |
| dc.subject | Optimization | |
| dc.subject | Parameters | |
| dc.subject | Chemistry | |
| dc.subject | Stability | |
| dc.subject | Am1 | |
| dc.title | Physicochemical study and characterization of the trimethoprim/2-hydroxypropyl-gamma-cyclodextrin inclusion complex | |
| dc.type | Artículos de revistas | |
