Characteristics of resistant hypertension: ageing, body mass index, hyperaldosteronism, cardiac hypertrophy and vascular stiffness

dc.creatorMartins, LC
dc.creatorFigueiredo, VN
dc.creatorQuinaglia, T
dc.creatorBoer-Martins, L
dc.creatorYugar-Toledo, JC
dc.creatorMartin, JFV
dc.creatorDemacq, C
dc.creatorPimenta, E
dc.creatorCalhoun, DA
dc.creatorMoreno, H
dc.date2011
dc.dateSEP
dc.date2014-07-30T16:51:48Z
dc.date2015-11-26T18:05:47Z
dc.date2014-07-30T16:51:48Z
dc.date2015-11-26T18:05:47Z
dc.date.accessioned2018-03-29T00:48:04Z
dc.date.available2018-03-29T00:48:04Z
dc.identifierJournal Of Human Hypertension. Nature Publishing Group, v. 25, n. 9, n. 532, n. 538, 2011.
dc.identifier0950-9240
dc.identifierWOS:000294027900003
dc.identifier10.1038/jhh.2010.95
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62769
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62769
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293219
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionResistant hypertension (RHTN) includes patients whose blood pressure (BP) is controlled with the use of four or more antihypertensive medications, and is referred to as 'controlled resistant hypertension' (CRH). While specifically comparing patients with CRH and uncontrolled resistant hypertension (UCRH), we hoped to identify distinguishing characteristics that would provide insight into factors contributing to resistance to antihypertensive therapies. RHTN patients were identified as controlled (CRH, n=43) or uncontrolled (UCRH, n=47). No statistical differences were observed between the CRH and UCRH subgroups with respect to age and gender. The body mass index, aldosterone-renin ratio and pulse wave velocity (PWV) were significantly higher in UCRH patients. Although both subgroups showed increased cardiac mass, left ventricular mass index was significantly higher in UCRH compared with CRH patients. Multivariate linear regression analysis indicated that PWV was significantly dependent on age in both UCRH and CRH patients; however, the influence of ageing was more pronounced in the former subgroup. Older age, greater vascular stiffness, higher aldosterone levels and greater left ventricular hypertrophy were significantly associated with lack of BP control in patients with RHTN. These findings suggest important possibilities in terms of preventing and better treating RHTN. Journal of Human Hypertension (2011) 25, 532-538; doi: 10.1038/jhh.2010.95; published online 7 October 2010
dc.description25
dc.description9
dc.description532
dc.description538
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherNature Publishing Group
dc.publisherLondon
dc.publisherInglaterra
dc.relationJournal Of Human Hypertension
dc.relationJ. Hum. Hypertens.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectresistant hypertension
dc.subjectcardiac hypertrophy
dc.subjectvascular stiffness
dc.subjectAngiotensin-aldosterone System
dc.subjectBlood-pressure Control
dc.subjectArterial Distensibility
dc.subjectCommittee
dc.subjectEchocardiography
dc.subjectRecommendations
dc.subjectPrevalence
dc.subjectSecretion
dc.subjectOutcomes
dc.subjectTherapy
dc.titleCharacteristics of resistant hypertension: ageing, body mass index, hyperaldosteronism, cardiac hypertrophy and vascular stiffness
dc.typeArtículos de revistas


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