Low nitric oxide bioavailability is associated with better responses to sildenafil in patients with erectile dysfunction

dc.creatorMuniz, JJ
dc.creatorLacchini, R
dc.creatorSertorio, JTC
dc.creatorJordao, AA
dc.creatorNobre, YTDA
dc.creatorTucci, S
dc.creatorMartins, ACP
dc.creatorTanus-Santos, JE
dc.date2013
dc.dateSEP
dc.date2014-07-30T13:39:03Z
dc.date2015-11-26T18:05:42Z
dc.date2014-07-30T13:39:03Z
dc.date2015-11-26T18:05:42Z
dc.date.accessioned2018-03-29T00:47:59Z
dc.date.available2018-03-29T00:47:59Z
dc.identifierNaunyn-schmiedebergs Archives Of Pharmacology. Springer, v. 386, n. 9, n. 805, n. 811, 2013.
dc.identifier0028-1298
dc.identifierWOS:000323515100006
dc.identifier10.1007/s00210-013-0882-z
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/52734
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/52734
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293197
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionErectile dysfunction (ED) is a multifactorial disease associated with vascular dysfunction, low nitric oxide (NO) bioavailability, and oxidative stress. However, it is not known whether low NO bioavailability and oxidative stress affect the responsiveness of ED patients to sildenafil. We tested this hypothesis by studying 28 healthy subjects (control group), 26 patients with ED without comorbidities (ED group), and 18 patients with ED and diabetes mellitus (ED/DM group). The International Index for Erectile Function (IIEF) questionnaire was used to assess the erectile function of all participants, and their responsiveness to sildenafil was assessed as the percentage of change in the five-item version of IIEF score before and after sildenafil treatment. Levels of whole blood nitrite, antioxidants markers (ferric reducing ability of plasma (FRAP) and reduced glutathione), and oxidative stress markers (thiobarbituric acid reactive substance and protein carbonyl) were determined. We found a negative correlation between whole blood nitrite levels and the responses to sildenafil in both ED groups (P < 0.05). FRAP correlated negatively with the responses to sildenafil in the ED/DM group (P < 0.05). No other significant associations were found. Our findings show evidence that low NO bioavailability is associated with better responses to sildenafil in patients with ED (with or without DM).
dc.description386
dc.description9
dc.description805
dc.description811
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherSpringer
dc.publisherNew York
dc.publisherEUA
dc.relationNaunyn-schmiedebergs Archives Of Pharmacology
dc.relationNaunyn-Schmiedebergs Arch. Pharmacol.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectErectile dysfunction
dc.subjectNitric oxide
dc.subjectNitrite
dc.subjectOxidative stress
dc.subjectSildenafil
dc.subjectSynthase Gene Haplotypes
dc.subjectMatrix Metalloproteinase-2 Activity
dc.subjectOxidative Stress
dc.subjectInternational Index
dc.subjectOral Sildenafil
dc.subjectPlasma
dc.subjectHypertension
dc.subjectInhibitors
dc.subjectTherapy
dc.subjectPathway
dc.titleLow nitric oxide bioavailability is associated with better responses to sildenafil in patients with erectile dysfunction
dc.typeArtículos de revistas


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