Risk factors and characteristics of ocular complications, and efficacy of autologous serum tears after haematopoietic progenitor cell transplantation

dc.creatorLeite, SC
dc.creatorde Castro, RS
dc.creatorAlves, M
dc.creatorCunha, DA
dc.creatorCorrea, MEP
dc.creatorda Silveira, LA
dc.creatorVigorito, AC
dc.creatorde Souza, CA
dc.creatorRocha, EM
dc.date2006
dc.dateAUG
dc.date2014-11-19T20:07:10Z
dc.date2015-11-26T18:05:41Z
dc.date2014-11-19T20:07:10Z
dc.date2015-11-26T18:05:41Z
dc.date.accessioned2018-03-29T00:47:58Z
dc.date.available2018-03-29T00:47:58Z
dc.identifierBone Marrow Transplantation. Nature Publishing Group, v. 38, n. 3, n. 223, n. 227, 2006.
dc.identifier0268-3369
dc.identifierWOS:000239118600009
dc.identifier10.1038/sj.bmt.1705426
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71120
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71120
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71120
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293194
dc.descriptionThe objective of the study was to evaluate the frequency and clinical characteristics of ocular complications and their risk factors, as well as autologous serum tears (AST) for the treatment of dry eye in these patients. Data from the files of 124 patients who had undergone allogeneic haematopoietic progenitor cell transplantation (HPCT) were evaluated. In addition, 33 HPCT patients were examined and their data were compared with controls. Analysis of tears and AST was performed. Dry eye manifestation occurred in 32% of patients and was positively correlated with age over 27 years (P=0.05), peripheral blood progenitor cell transplant (P=0.002), chronic graft-versus-host disease (P=0.0027), and chronic or acute myeloid leukaemia (P=0.001). Dry mouth and Schirmer test < 5mm were predictive factors for dry eye in HPCT patients (P=0.002 and odds ratio 3.9 and P=0.007, odds ratio=5.9, respectively). Microbiological analysis revealed that six of 11 AST samples were contaminated after 30 days of use. The present study supports the role of potential risk factors for ocular complications and key elements to detect alterations in the tear film from HPCT patients. In addition, AST contamination must be considered after longer periods of use.
dc.description38
dc.description3
dc.description223
dc.description227
dc.languageen
dc.publisherNature Publishing Group
dc.publisherLondon
dc.publisherInglaterra
dc.relationBone Marrow Transplantation
dc.relationBone Marrow Transplant.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectdry eye
dc.subjectautologous serum tears
dc.subjectleukaemia
dc.subjectinsulin
dc.subjectinterleukin-1 beta
dc.subjectBone-marrow-transplantation
dc.subjectVersus-host-disease
dc.subjectDry Eye Disease
dc.subjectSjogrens-syndrome
dc.subjectHematologic Malignancies
dc.subjectGraft
dc.subjectDrops
dc.subjectContamination
dc.subjectManagement
dc.subjectPathology
dc.titleRisk factors and characteristics of ocular complications, and efficacy of autologous serum tears after haematopoietic progenitor cell transplantation
dc.typeArtículos de revistas


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