Multivariate control charts based on net analyte signal (NAS) and Raman spectroscopy for quality control of carbamazepine

dc.creatorRocha, WFD
dc.creatorPoppi, RJ
dc.date2011
dc.dateOCT 31
dc.date2014-08-01T18:40:24Z
dc.date2015-11-26T18:05:40Z
dc.date2014-08-01T18:40:24Z
dc.date2015-11-26T18:05:40Z
dc.date.accessioned2018-03-29T00:47:58Z
dc.date.available2018-03-29T00:47:58Z
dc.identifierAnalytica Chimica Acta. Elsevier Science Bv, v. 705, n. 41671, n. 35, n. 40, 2011.
dc.identifier0003-2670
dc.identifierWOS:000295993900006
dc.identifier10.1016/j.aca.2011.03.024
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/82052
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/82052
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293193
dc.descriptionRaman spectroscopy and control charts based on the net analyte signal (NAS) were applied to polymorphic characterization of carbamazepine. Carbamazepine presents four polymorphic forms: I-IV (dihydrate). Xray powder diffraction was used as a reference technique. The control charts were built generating three charts: the NAS chart that corresponds to the analyte of interest (form III in this case), the interference chart that corresponds to the contribution of other compounds in the sample and the residual chart that corresponds to nonsystematic variations. For each chart, statistical limits were developed using samples within the quality specifications. It was possible to identify the different polymorphic forms of carbamazepine present in pharmaceutical formulations. Thus, an alternative method for the quality monitoring of the carbamazepine polymorphic forms after the crystallization process is presented. (C) 2011 Elsevier B.V. All rights reserved.
dc.description705
dc.description41671
dc.descriptionSI
dc.description35
dc.description40
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationAnalytica Chimica Acta
dc.relationAnal. Chim. Acta
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectRaman spectroscopy
dc.subjectNet analyte signal
dc.subjectMultivariate control charts
dc.subjectCarbamazepine
dc.subjectNear-infrared Spectroscopy
dc.subjectSolid-state
dc.subjectPolymorphs
dc.subjectCrystallization
dc.subjectDihydrate
dc.subjectNimesulide
dc.subjectKinetics
dc.subjectDesign
dc.subjectForms
dc.titleMultivariate control charts based on net analyte signal (NAS) and Raman spectroscopy for quality control of carbamazepine
dc.typeArtículos de revistas


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