Characteristics of nasal T/NK-cell lymphoma among brazilians

dc.creatorAltemani, A
dc.creatorBarbosa, AC
dc.creatorKulka, M
dc.creatorTakahashi, T
dc.creatorEndo, L
dc.creatorVassallo, J
dc.creatorLorand-Metze, I
dc.date2002
dc.date2014-07-30T16:51:47Z
dc.date2015-11-26T18:05:21Z
dc.date2014-07-30T16:51:47Z
dc.date2015-11-26T18:05:21Z
dc.date.accessioned2018-03-29T00:47:40Z
dc.date.available2018-03-29T00:47:40Z
dc.identifierNeoplasma. Veda, Slovak Academy Sciences, v. 49, n. 1, n. 55, n. 60, 2002.
dc.identifier0028-2685
dc.identifierWOS:000174723500011
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62767
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62767
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293119
dc.descriptionNasal T/NK-cell lymphomas are highly associated with Epstein-Barr virus (EBV). They are more frequent in Asia than in Western countries. In Central and South America there are few studies about nasal T/NK-cell lymphoma and they have shown a strong predominance of this phenotype in Native American descents, supporting the hypothesis of a racial predisposition for the disease. We studied the lymphomas involving midline facial region at a Brazilian institution. T/NK cell lymphomas (16/25) were more frequently found compared to B lymphomas (9 cases, all B large cell). T/NK cell lymphomas involved predominantly the nasal region. Histologically they showed angioinvasion and necrosis. All of them were positive for CD3 and CD56 and showed numerous tumor cells labeled by EBER-1. Although disease was localized in 61% at diagnosis, there was no tendency to cure. The racial distribution of patients with T/NK-cell phenotype was similar to that found in B-cell lymphomas. EBV was more frequently found in adenoids than in palatine tonsils. In inflammatory lesions of the nasal and palatal regions EBV was not found. In the present study the relative frequency of T/NK versus B cell sinonasal lymphomas was high and similar to that observed in other Latin American countries. However, there was not any racial association with T/NK-cell phenotype and the tumor showed an agressive behavior similar to that reported in Asia. The high frequency of EBV-positive lymphocytes in nasopharyngeal lymphoid tissue (adenoids) suggests that they could serve as a reservoir for the virus.
dc.description49
dc.description1
dc.description55
dc.description60
dc.languageen
dc.publisherVeda, Slovak Academy Sciences
dc.publisherBrastislava
dc.publisherEslováquia
dc.relationNeoplasma
dc.relationNeoplasma
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectlymphoma
dc.subjectT/NK cell
dc.subjectnose
dc.subjectEpstein-Barr virus
dc.subjectEpstein-barr-virus
dc.subjectNon-hodgkins-lymphoma
dc.subjectMalignant-lymphomas
dc.subjectImmunophenotype
dc.subjectInfection
dc.subjectPeru
dc.subjectHead
dc.subjectNeck
dc.titleCharacteristics of nasal T/NK-cell lymphoma among brazilians
dc.typeArtículos de revistas


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