Effect of BJcuL (a lectin from the venom of the snake Bothrops jararacussu) on adhesion and growth of tumor and endothelial cells

dc.creatorde Carvalho, DD
dc.creatorSchmitmeier, S
dc.creatorNovello, JC
dc.creatorMarkland, FS
dc.date2001
dc.dateOCT
dc.date2014-11-19T18:58:10Z
dc.date2015-11-26T18:05:08Z
dc.date2014-11-19T18:58:10Z
dc.date2015-11-26T18:05:08Z
dc.date.accessioned2018-03-29T00:47:26Z
dc.date.available2018-03-29T00:47:26Z
dc.identifierToxicon. Pergamon-elsevier Science Ltd, v. 39, n. 10, n. 1471, n. 1476, 2001.
dc.identifier0041-0101
dc.identifierWOS:000170547900004
dc.identifier10.1016/S0041-0101(01)00106-4
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63767
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/63767
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63767
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293059
dc.descriptionLectins are polyvalent carbohydrate-binding proteins of non-immune origin. Recently, we have isolated and characterized a lectin from the venom of the snake Bothrops jararacussu. This lectin (BJcuL) has been shown to bind to lactose moieties and induce agglutination of erythrocytes. In the present work, we observed that cells from human metastatic breast cancer (MDA-MB-435) and human ovarian carcinoma (OVCAR-5) cell lines adhere, although weakly, to BJcuL. However, BJcuL did not inhibit adhesion of these cells to the extracellular matrix proteins fibronectin, laminin and type I collagen. Importantly, viability of these tumor cells and cells from other human tumor cell lines and a bovine brain endothelial cell line was suppressed by BJcuL. These findings suggest that the lectin BJcuL may serve as an interesting tool for combating tumor progression by inhibiting tumor cell and endothelial cell growth. (C) 2001 Elsevier Science Ltd. All rights reserved.
dc.description39
dc.description10
dc.description1471
dc.description1476
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationToxicon
dc.relationToxicon
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectsnake venom
dc.subjectlectin
dc.subjectBJcuL
dc.subjectcytotoxicity
dc.subjecttumor cells
dc.subjectendothelial cells
dc.subjectGalactoside-specific Lectin
dc.subjectMelanoma-cells
dc.subjectCancer
dc.subjectProliferation
dc.subjectMistletoe
dc.subjectGlioma
dc.subjectLines
dc.titleEffect of BJcuL (a lectin from the venom of the snake Bothrops jararacussu) on adhesion and growth of tumor and endothelial cells
dc.typeArtículos de revistas


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