Morphological evaluation of combined effects of cyclosporin and nifedipine on gingival overgrowth in rats

dc.creatorSpolidorio, LC
dc.creatorSpolidorio, DM
dc.creatorNeves, KA
dc.creatorGonzaga, HFS
dc.creatorAlmeida, OP
dc.date2002
dc.dateJUN
dc.date2014-08-01T18:41:48Z
dc.date2015-11-26T18:05:06Z
dc.date2014-08-01T18:41:48Z
dc.date2015-11-26T18:05:06Z
dc.date.accessioned2018-03-29T00:47:23Z
dc.date.available2018-03-29T00:47:23Z
dc.identifierJournal Of Periodontal Research. Wiley-blackwell, v. 37, n. 3, n. 192, n. 195, 2002.
dc.identifier0022-3484
dc.identifier1600-0765
dc.identifierWOS:000176359100004
dc.identifier10.1034/j.1600-0765.2002.00028.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/82210
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/82210
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293047
dc.descriptionIt has previously been shown that, while cyclosporin A (CsA) and nifedipine both cause gingival overgrowth in the rat, the combined use of these drugs increases the severity of overgrowth. The nine of this study was to describe the histometry and densities of fibroblasts, collagen fibers and vessels in the gingival tissue of rats that were treated with CsA and nifedipine, either alone or in combination. Rats were treated for 60 days with a daily subcutaneous injection of 10 mg/kg body weight of CsA and/or with 50 mg/kg body weight of nifedipine added to the chow. The results confirmed that CsA causes a more severe overgrowth than nifedipine. and that the combined use of these drugs increases the overgrowth severity. All the rat groups that were studied showed that. as the severity of overgrowth increased, there was a parallel increase in fibroblasts and collagen, and a decrease in vessel content. Therefore, independently of whether the gingival overgrowth was caused by CsA alone, nifedipine alone, or both treatments in combination, the fibroblast and collagen density increased in parallel with the severity of the overgrowth.
dc.description37
dc.description3
dc.description192
dc.description195
dc.languageen
dc.publisherWiley-blackwell
dc.publisherHoboken
dc.publisherEUA
dc.relationJournal Of Periodontal Research
dc.relationJ. Periodont. Res.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectcyclosporin A
dc.subjectnifedipine
dc.subjectgingival overgrowth
dc.subjectRenal-transplant Patients
dc.subjectHuman-fibroblasts
dc.subjectHyperplasia
dc.subjectSeverity
dc.subjectPhenytoin
dc.subjectGrowth
dc.titleMorphological evaluation of combined effects of cyclosporin and nifedipine on gingival overgrowth in rats
dc.typeArtículos de revistas


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