Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients

dc.creatorPereira, JKN
dc.creatorTraina, F
dc.creatorMachado-Neto, JA
dc.creatorDuarte, ADS
dc.creatorLopes, MR
dc.creatorSaad, STO
dc.creatorFavaro, P
dc.date2012
dc.dateOCT
dc.date2014-07-30T14:50:39Z
dc.date2015-11-26T18:05:06Z
dc.date2014-07-30T14:50:39Z
dc.date2015-11-26T18:05:06Z
dc.date.accessioned2018-03-29T00:47:22Z
dc.date.available2018-03-29T00:47:22Z
dc.identifierLeukemia Research. Pergamon-elsevier Science Ltd, v. 36, n. 10, n. 1300, n. 1303, 2012.
dc.identifier0145-2126
dc.identifierWOS:000308044100017
dc.identifier10.1016/j.leukres.2012.06.010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62554
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62554
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293044
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionRecent studies have indicated the Musashi2/NUMB pathway as the key regulator of differentiation in chronic myeloid leukemia; however, a comparison of both gene expressions has not yet been made in myelodysplastic syndrome (MDS) and in acute myeloid leukemia (AML). We herein, demonstrate a statistically significant down-modulation of NUMB expression level in high-risk MDS and AML, compared with control individuals. MSI2 expression was significantly reduced in low and high-risk MDS compared with normal control samples. NUMB expression was significantly lower than that of MSI2 in both MDS and AML patient samples, but no differences in the expression levels for either gene were observed in healthy bone marrow cells. Finally, NUMB expression was significantly up-regulated during differentiation of normal and low-risk MDS CD34(+) cells through the erythroid lineage. Taken together, results suggest the involvement of NUMB in MDS erythropoiesis; its down-modulation may have a role in MDS progression. (C) 2012 Elsevier Ltd. All rights reserved.
dc.description36
dc.description10
dc.description1300
dc.description1303
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationLeukemia Research
dc.relationLeuk. Res.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectMusashi 2
dc.subjectNUMB
dc.subjectMyelodysplastic syndromes
dc.subjectAcute myeloid leukemia
dc.subjectDifferentiation
dc.subjectPathogenesis
dc.titleDistinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
dc.typeArtículos de revistas


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