Lymphocyte activation in silica-exposed workers

dc.creatorRocha-Parise, M
dc.creatorSantos, LMB
dc.creatorDamoiseaux, JGMC
dc.creatorBagatin, E
dc.creatorLido, AV
dc.creatorTorello, CO
dc.creatorTervaert, JWC
dc.creatorQueiroz, MLS
dc.date2014
dc.dateAPR-MAY
dc.date2014-08-01T18:36:04Z
dc.date2015-11-26T18:04:55Z
dc.date2014-08-01T18:36:04Z
dc.date2015-11-26T18:04:55Z
dc.date.accessioned2018-03-29T00:47:07Z
dc.date.available2018-03-29T00:47:07Z
dc.identifierInternational Journal Of Hygiene And Environmental Health. Elsevier Gmbh, Urban & Fischer Verlag, v. 217, n. 41763, n. 586, n. 591, 2014.
dc.identifier1438-4639
dc.identifier1618-131X
dc.identifierWOS:000335113500018
dc.identifier10.1016/j.ijheh.2013.11.002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81326
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81326
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1292978
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionExposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1 alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders. (C) 2013 Elsevier GmbH. All rights reserved.
dc.description217
dc.description41763
dc.description586
dc.description591
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2001/13823-8, 2007/53901-4]
dc.descriptionCNPq [301702/2005-5, 300575/2008-4]
dc.languageen
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.publisherJena
dc.publisherAlemanha
dc.relationInternational Journal Of Hygiene And Environmental Health
dc.relationInt. J. Hyg. Environ. Health.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectLymphocytes
dc.subjectSoluble IL-2 receptor alpha
dc.subjectInterleukin-2
dc.subjectSilica
dc.subjectCytokines
dc.subjectAutoimmunity
dc.subjectSoluble Interleukin-2 Receptor
dc.subjectT-cell-activation
dc.subjectRheumatoid-arthritis
dc.subjectNalp3 Inflammasome
dc.subjectAutoimmune-disease
dc.subjectIn-vitro
dc.subjectCytokines
dc.subjectAutoantibodies
dc.subjectExpression
dc.subjectExpansion
dc.titleLymphocyte activation in silica-exposed workers
dc.typeArtículos de revistas


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