Solid films of blended poly(vinyl alcohol)/poly(vinyl pyrrolidone) for topical S-nitrosoglutathione and nitric oxide release

dc.creatorSeabra, AB
dc.creatorDa Rocha, LL
dc.creatorEberlin, MN
dc.creatorDe Oliveira, MG
dc.date2005
dc.dateMAY
dc.date2014-11-19T17:15:29Z
dc.date2015-11-26T18:04:39Z
dc.date2014-11-19T17:15:29Z
dc.date2015-11-26T18:04:39Z
dc.date.accessioned2018-03-29T00:46:48Z
dc.date.available2018-03-29T00:46:48Z
dc.identifierJournal Of Pharmaceutical Sciences. John Wiley & Sons Inc, v. 94, n. 5, n. 994, n. 1003, 2005.
dc.identifier0022-3549
dc.identifierWOS:000228792200008
dc.identifier10.1002/jps.20314
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71787
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71787
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71787
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1292913
dc.descriptionNitric oxide (NO) is responsible for biological actions in mammals, ranging from the control of arterial pressure to immunological responses. In this study, S-nitrosoglutathione (GSNO), a spontaneous NO donor, was incorporated in solid films of blended poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP) comprising a biomaterial with potential for the local delivery of NO. In dry conditions, the extinction of the absorption bands of GSNO was correlated with the increase of the absorption band of its dimmer, GS-SG, implying NO release through the homolytic cleavage of the S-N bond. Mass spectrometry was used to confirm and to monitor the release of free NO from solid PVA/PVP-GSNO films to the gas phase. Kinetic measurement based on the Griess reaction was used to show that solid PVA/PVP-GSNO films are also capable of releasing both NO and GSNO to aqueous solution trough diffusion. Storage experiments have shown that GSNO is highly stabilized in the dry PVA/PVP matrix. The results indicate that GSNO-containing PVA/PVP films may be used for delivering free NO and/or GSNO topically and controllably. (c) 2005 Wiley-Liss, Inc. and the American Pharmacists Association.
dc.description94
dc.description5
dc.description994
dc.description1003
dc.languageen
dc.publisherJohn Wiley & Sons Inc
dc.publisherHoboken
dc.publisherEUA
dc.relationJournal Of Pharmaceutical Sciences
dc.relationJ. Pharm. Sci.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectnitric oxide detection
dc.subjectS-nitrosoglutathione
dc.subjectpoly(vinyl alcohol)
dc.subjectpoly(vinyl pyrrolidone)
dc.subjectnitric oxide delivery
dc.subjectmass spectrometry
dc.subjectUV/Vis spectroscopy
dc.subjectpolymeric drug delivery systems
dc.subjecttargeted drug delivery
dc.subjectpolymeric biomaterials
dc.subjectVolatile Organic-compounds
dc.subjectNitroso-n-acetylcysteine
dc.subjectMass-spectrometry
dc.subjectExpression
dc.subjectSynthase
dc.subjectAlcohol)
dc.subjectNitrate
dc.subjectPlasma
dc.subjectDonors
dc.titleSolid films of blended poly(vinyl alcohol)/poly(vinyl pyrrolidone) for topical S-nitrosoglutathione and nitric oxide release
dc.typeArtículos de revistas


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