| dc.creator | Freire, MGM | |
| dc.creator | Desouza, IA | |
| dc.creator | Silva, ACM | |
| dc.creator | Macedo, MLR | |
| dc.creator | Lima, MS | |
| dc.creator | Tamashiro, WMSC | |
| dc.creator | Antunes, E | |
| dc.creator | Marangoni, S | |
| dc.date | 2003 | |
| dc.date | SEP | |
| dc.date | 2014-11-19T16:37:54Z | |
| dc.date | 2015-11-26T18:04:13Z | |
| dc.date | 2014-11-19T16:37:54Z | |
| dc.date | 2015-11-26T18:04:13Z | |
| dc.date.accessioned | 2018-03-29T00:46:19Z | |
| dc.date.available | 2018-03-29T00:46:19Z | |
| dc.identifier | Toxicon. Pergamon-elsevier Science Ltd, v. 42, n. 3, n. 275, n. 280, 2003. | |
| dc.identifier | 0041-0101 | |
| dc.identifier | WOS:000185217300007 | |
| dc.identifier | 10.1016/S0041-0101(03)00142-9 | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60167 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/60167 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/60167 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1292788 | |
| dc.description | A novel lectin from Talisia esculenta seeds (TEL) has recently been purified and characterized. In this study we investigated the proinflammatory activity of TEL in mice using both the air-pouch and peritoneal cavity as well as paw oedema models. TEL (10-40 mug) induced significant neutrophil and mononuclear cell recruitment when injected into either mouse air-pouch or peritoneal cavity. The neutrophil accumulation into the air-pouch was dose- and time-dependent with a maximal response at 16 h. returning to control levels at 72 h whereas maximal mononuclear cell accumulation was observed at 24 h after TEL injection. The same profile of neutrophil accumulation was observed when this lectin was injected into mouse peritonea] cavity, although the maximal mononuclear cell recruitment was observed 48 h after TEL injection. Additionally, TEL (12.5-200 mug/paw) caused a dose-dependent mice paw, as evaluated at 4 h after the lectin injection. D-mannose, better than D-glucose, significantly inhibited TEL-induced neutrophil migration into the peritoneal cavity or air-pouch. D-galactose had no effect on TEL-induced neutrophil migration in either cavity studied. On the other hand, D-mannose slightly inhibited the TEL-induced paw oedema. whereas neither D-glucose nor D-galactose affected this phenomenon. In conclusion, our data show that TEL induces neutrophil and mononuclear cell accumulation by a mechanism related to their specific sugar-binding properties. (C) 2003 Elsevier Ltd. All rights reserved. | |
| dc.description | 42 | |
| dc.description | 3 | |
| dc.description | 275 | |
| dc.description | 280 | |
| dc.language | en | |
| dc.publisher | Pergamon-elsevier Science Ltd | |
| dc.publisher | Oxford | |
| dc.publisher | Inglaterra | |
| dc.relation | Toxicon | |
| dc.relation | Toxicon | |
| dc.rights | fechado | |
| dc.rights | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
| dc.source | Web of Science | |
| dc.subject | Talisia esculenta lectin | |
| dc.subject | mouse paw oedema | |
| dc.subject | leukocyte immigration | |
| dc.subject | Plant-lectins | |
| dc.subject | Lymphocyte-activation | |
| dc.subject | In-vivo | |
| dc.subject | Agglutinin | |
| dc.subject | Defense | |
| dc.subject | Mart | |
| dc.title | Inflammatory responses induced in mice by lectin from Talisia esculenta seeds | |
| dc.type | Artículos de revistas | |
