Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice

dc.creatorRopelle, ER
dc.creatorPauli, JR
dc.creatorCintra, DE
dc.creatorda Silva, AS
dc.creatorDe Souza, CT
dc.creatorGuadagnini, D
dc.creatorCarvalho, BM
dc.creatorCaricilli, AM
dc.creatorKatashima, CK
dc.creatorCarvalho, MA
dc.creatorHirabara, S
dc.creatorCuri, R
dc.creatorVelloso, LA
dc.creatorSaad, MJA
dc.creatorCarvalheira, JBC
dc.date2013
dc.dateFEB
dc.date2014-08-01T18:26:47Z
dc.date2015-11-26T18:03:26Z
dc.date2014-08-01T18:26:47Z
dc.date2015-11-26T18:03:26Z
dc.date.accessioned2018-03-29T00:45:20Z
dc.date.available2018-03-29T00:45:20Z
dc.identifierDiabetes. Amer Diabetes Assoc, v. 62, n. 2, n. 466, n. 470, 2013.
dc.identifier0012-1797
dc.identifierWOS:000314263600022
dc.identifier10.2337/db12-0339
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79046
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79046
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1292540
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAccumulating evidence has demonstrated that S-nitrosation of proteins plays a critical role in several human diseases. Here, we explored the role of inducible nitric oxide synthase (iNOS) in the S-nitrosation of proteins involved in the early steps of the insulin-signaling pathway and insulin resistance in the skeletal muscle of aged mice. Aging increased iNOS expression and S-nitrosation of major proteins involved in insulin signaling, thereby reducing insulin sensitivity in skeletal muscle. Conversely, aged iNOS-null mice were protected from S-nitrosation-induced insulin resistance. Moreover, pharmacological treatment with an iNOS inhibitor and acute exercise reduced iNOS-induced S-nitrosation and increased insulin sensitivity in the muscle of aged animals. These findings indicate that the insulin resistance observed in aged mice is mainly mediated through the S-nitrosation of the insulin-signaling pathway. Diabetes 62:466-470, 2013
dc.description62
dc.description2
dc.description466
dc.description470
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherAmer Diabetes Assoc
dc.publisherAlexandria
dc.publisherEUA
dc.relationDiabetes
dc.relationDiabetes
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectAkt/protein Kinase-b
dc.subjectReceptor Substrate-1
dc.subjectTyrosine Nitration
dc.subjectNitrosylation
dc.subjectObesity
dc.subjectInflammation
dc.subjectDysfunction
dc.subjectProteins
dc.subjectExercise
dc.subjectB/akt
dc.titleTargeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice
dc.typeArtículos de revistas


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