Brasil | Artículos de revistas

Toll-Like Receptor 6 Ser249Pro Polymorphism Is Associated With Lower Left Ventricular Wall Thickness and Inflammatory Response in Hypertensive Women

dc.creatorSales, ML
dc.creatorSchreiber, R
dc.creatorFerreira-Sae, MCS
dc.creatorFernandes, MN
dc.creatorPiveta, CSC
dc.creatorCipolli, JAA
dc.creatorCardoso, CC
dc.creatorMatos-Souza, JR
dc.creatorGeloneze, B
dc.creatorFranchini, KG
dc.creatorNadruz, W
dc.date2010
dc.dateJUN
dc.date2014-08-01T18:21:29Z
dc.date2015-11-26T18:03:21Z
dc.date2014-08-01T18:21:29Z
dc.date2015-11-26T18:03:21Z
dc.date.accessioned2018-03-29T00:45:12Z
dc.date.available2018-03-29T00:45:12Z
dc.identifierAmerican Journal Of Hypertension. Nature Publishing Group, v. 23, n. 6, n. 649, n. 654, 2010.
dc.identifier0895-7061
dc.identifierWOS:000278041700012
dc.identifier10.1038/ajh.2010.24
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77696
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77696
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1292507
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionBACKGROUND Experimental data demonstrated that inactivation of toll-like receptor (TLR) pathway components attenuated left ventricular (LV) remodeling induced by pressure overload.This study investigated the impact of TLR6 Ser249Pro polymorphism on LV structure in hypertensive subjects. METHODS A sample of 443 patients (266 women and 177 men) was evaluated by clinical history, physical examination, analysis of inflammatory and metabolic parameters, echocardiography, and genotyping of the TLR6 variant. Moreover, the relationship between genotypes and in vitro responsiveness of peripheral blood monocytic cells to TLR agonists was also assessed. RESULTS Homozygous women for the TLR6 2495er allele had lower LV posterior wall thickness (9.4 +/- 0.4 vs. 10.5 +/- 0.1 mm; P=0.02), interventricular septum thickness (9.7 +/- 0.3 vs. 10.7 +/- 0.1 mm; P = 0.03), and LV relative wall thickness (0.39 +/- 0.02 vs. 0.44 +/- 0.01; P = 0.02) than women with other genotypes. These results were confirmed by stepwise regression analyses adjusted by potential confounders. Conversely, homozygous men for the 2495er variant showed no differences in LV structure in comparison to males carrying the 249Pro allele. In addition, monocytes from hypertensive women homozygous for the 2495er allele showed a lower release of tumor necrosis factor-a and interleukin-6 in response to zymosan (TLR6 agonist), but not to lipopolysaccharide (TLR4 agonist). CONCLUSION These data suggest that hypertensive women homozygous for the TLR6 249Ser polymorphism might exhibit lower LV wall thickness and reduced TLR6-mediated inflammatory response than females carrying the major allele.
dc.description23
dc.description6
dc.description649
dc.description654
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [05/56986-5, 08/10069-0]
dc.descriptionCNPq [304329/06-1, 474206/07-6]
dc.languageen
dc.publisherNature Publishing Group
dc.publisherNew York
dc.publisherEUA
dc.relationAmerican Journal Of Hypertension
dc.relationAm. J. Hypertens.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectblood pressure
dc.subjectgender
dc.subjecthypertension
dc.subjectleft ventricle
dc.subjectpolymorphism
dc.subjecttoll-like receptor
dc.subjectSex-differences
dc.subjectCardiovascular-disease
dc.subjectCardiac-hypertrophy
dc.subjectPressure-overload
dc.subjectObesity
dc.subjectGender
dc.subjectTlr6
dc.subjectGeometry
dc.subjectProgram
dc.subjectAsthma
dc.titleToll-Like Receptor 6 Ser249Pro Polymorphism Is Associated With Lower Left Ventricular Wall Thickness and Inflammatory Response in Hypertensive Women
dc.typeArtículos de revistas


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