Glatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion

dc.creatorScorisa, JM
dc.creatorZanon, RG
dc.creatorFreria, CM
dc.creatorde Oliveira, ALR
dc.date2009
dc.dateFEB 13
dc.date2014-11-19T12:59:08Z
dc.date2015-11-26T18:03:18Z
dc.date2014-11-19T12:59:08Z
dc.date2015-11-26T18:03:18Z
dc.date.accessioned2018-03-29T00:45:08Z
dc.date.available2018-03-29T00:45:08Z
dc.identifierNeuroscience Letters. Elsevier Ireland Ltd, v. 451, n. 1, n. 34, n. 39, 2009.
dc.identifier0304-3940
dc.identifierWOS:000263656600008
dc.identifier10.1016/j.neulet.2008.12.017
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68071
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/68071
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68071
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1292490
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAvulsion of ventral roots induces degeneration of most axotomized motoneurons. At present there are no effective strategies to prevent such neuronal loss and to preserve the affected spinal circuits. Interestingly, changes in the spinal cord network also occur during the course of the experimental model of multiple sclerosis (experimental autoimmune encephalomyelitis-EAE). Glatiramer acetate (GA) significantly reduces the seriousness of the symptoms during the exacerbation of EAE. However, little is known about its effects on motoneurons. In the present study, we investigated whether GA has an influence on synapse plasticity and glial reaction after ventral root avulsion (VRA). Lewis rats were subjected to the avulsion of lumbar ventral roots and treated with GA. The animals were sacrificed after 14 days of treatment and the spinal cords processed for immunohistochemistry. A correlation between the synaptic changes and glial activation was obtained by performing immunolabeling against synaptophysin, GFAP and Iba-1. GA treatment preserved synaptophysin labeling, and significantly reduced the glial reaction in the area surrounding the axotomized motoneurons. After ventral root avulsion, GA treatment was also neuroprotective. The present results indicate that the immunomodulator GA has an influence on the stability of nerve terminals in the spinal cord, which may in turn contribute to future treatment strategies after proximal lesions to spinal motoneurons. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
dc.description451
dc.description1
dc.description34
dc.description39
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationNeuroscience Letters
dc.relationNeurosci. Lett.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectVentral root avulsion
dc.subjectSpinal cord
dc.subjectSynapse elimination
dc.subjectMotoneuron
dc.subjectImmunomodulator
dc.subjectGlatiramer acetate
dc.subjectExperimental Autoimmune Encephalomyelitis
dc.subjectMultiple-sclerosis
dc.subjectCopolymer 1
dc.subjectTherapy
dc.subjectCells
dc.subjectMhc
dc.subjectNeuroprotection
dc.subjectRegeneration
dc.subjectExpression
dc.subjectNeurons
dc.titleGlatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución