Neurovisual abnormalities preceding the retinopathy in patients with long-term type 1 diabetes mellitus

dc.creatorde Faria, JML
dc.creatorKatsumi, O
dc.creatorCagliero, E
dc.creatorNathan, D
dc.creatorHirose, T
dc.date2001
dc.dateSEP
dc.date2014-11-19T10:16:28Z
dc.date2015-11-26T18:02:19Z
dc.date2014-11-19T10:16:28Z
dc.date2015-11-26T18:02:19Z
dc.date.accessioned2018-03-29T00:43:59Z
dc.date.available2018-03-29T00:43:59Z
dc.identifierGraefes Archive For Clinical And Experimental Ophthalmology. Springer-verlag, v. 239, n. 9, n. 643, n. 648, 2001.
dc.identifier0721-832X
dc.identifierWOS:000171481500002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65317
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/65317
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65317
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1292196
dc.descriptionBackground: Changes in the retina caused by diabetes may lead to visual impairment in dim light, even with good visual acuity and visual fields. To evaluate the visual abnormalities preceding the retinopathy in patients with type 1 diabetes mellitus (DM), we applied electrophysiological methods. Methods: The visual evoked responses were recorded with sinusoidally modulated vertical gratings at 10 spatial frequencies presented sequentially on a high-resolution monitor in patients with type 1 DM and in normal volunteers. Similarly, the contrast visual evoked responses of 10 contrast levels were recorded at five spatial frequencies. Both amplitudes at the second harmonic were calculated by discrete Fourier transform. The visual acuity and contrast thresholds were determined objectively. Results: There was dissociation between the Snellen and the estimated visual evoked response acuity measurements in patients with diabetes (r(2)=0.077, P=0.44). The saturation phenomena were observed at lower levels of contrast stimuli than in normal individuals at. 1.0, 2.0, 4.0 and 8.0 cycles per degree (P=0.0001). The contrast sensitivity function was deeply abnormal in all tested patients despite the metabolic control. The values of the area under the curve of the visual evoked response amplitude-contrast level function at five spatial frequencies were smaller in patients with DM than in the control group (P <0.05) at all spatial frequencies tested. Conclusions: Patients with type 1 DM without retinopathy showed significant lower amplitude of the visual evoked responses at all spatial frequencies tested, with the saturation phenomena observed at lower level of contrast stimuli. In addition, there was a dissociation between the sweep visual evoked responses and the Snellen acuity measurements. A significant and nonselective neuronal visual loss involving the visual pathway precedes the ophthalmoscopically detectable retinopathy in patients with type 1 DM.
dc.description239
dc.description9
dc.description643
dc.description648
dc.languageen
dc.publisherSpringer-verlag
dc.publisherNew York
dc.publisherEUA
dc.relationGraefes Archive For Clinical And Experimental Ophthalmology
dc.relationGraefes Arch. Clin. Exp. Ophthalmol.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectContrast Sensitivity Function
dc.subjectVisual-evoked-responses
dc.subjectOscillatory Potentials
dc.subjectObjective Assessment
dc.subjectElectroretinogram
dc.subjectAcuity
dc.subjectRetina
dc.subjectPattern
dc.subjectDysfunction
dc.subjectInsulin
dc.titleNeurovisual abnormalities preceding the retinopathy in patients with long-term type 1 diabetes mellitus
dc.typeArtículos de revistas


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