PROTECTIVE EFFECT OF TRIFLUOPERAZINE ON THE MITOCHONDRIAL DAMAGE INDUCED BY CA-2+ PLUS PROOXIDANTS

dc.creatorPEREIRA, RS
dc.creatorBERTOCCHI, APF
dc.creatorVERCESI, AE
dc.date1992
dc.date37926
dc.date2014-12-16T11:34:36Z
dc.date2015-11-26T18:02:06Z
dc.date2014-12-16T11:34:36Z
dc.date2015-11-26T18:02:06Z
dc.date.accessioned2018-03-29T00:43:45Z
dc.date.available2018-03-29T00:43:45Z
dc.identifierBiochemical Pharmacology. Pergamon-elsevier Science Ltd, v. 44, n. 9, n. 1795, n. 1801, 1992.
dc.identifier0006-2952
dc.identifierWOS:A1992JZ90300015
dc.identifier10.1016/0006-2952(92)90074-S
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58310
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/58310
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58310
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1292141
dc.descriptionIsolated rat liver mitochondria undergo extensive swelling and disruption of membrane potential when they accumulate Ca2+ in the presence of a prooxidant such as diamide or t-butylhydroperoxide. The phenothiazinic drug trifluoperazine, at concentrations (15-35 muM) which do not inhibit respiration or the influx of Ca2+ into mitochondria, significantly protected mitochondria against the deleterious effects of Ca2+ plus a prooxidant. In contrast, at concentrations higher than 100 muM the drug potentiated these deleterious effects of Ca2+ and prooxidants and had a damaging effect per se on the inner mitochondrial membrane. It is proposed that the protection conferred by the drug is mediated by changes in membrane protein structure that decrease the production of protein thiol cross-linkings which occur when mitochondria accumulate calcium under oxidant stress conditions.
dc.description44
dc.description9
dc.description1795
dc.description1801
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationBiochemical Pharmacology
dc.relationBiochem. Pharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectRat-heart Mitochondria
dc.subjectLiver-mitochondria
dc.subjectMembrane
dc.subjectInhibition
dc.subjectRelease
dc.subjectCalcium
dc.subjectCa2+
dc.subjectCalmodulin
dc.subjectTransport
dc.subjectCalmidazolium
dc.titlePROTECTIVE EFFECT OF TRIFLUOPERAZINE ON THE MITOCHONDRIAL DAMAGE INDUCED BY CA-2+ PLUS PROOXIDANTS
dc.typeArtículos de revistas


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