Tubular variant of basal cell adenoma shares immunophenotypical features with normal intercalated ducts and is closely related to intercalated duct lesions of salivary gland

dc.creatorMontalli, VA
dc.creatorMartinez, E
dc.creatorTincani, A
dc.creatorMartins, A
dc.creatorAbreu, MD
dc.creatorNeves, C
dc.creatorCosta, AF
dc.creatorde Araujo, VC
dc.creatorAltemani, A
dc.date2014
dc.dateMAY
dc.date2014-08-01T18:19:03Z
dc.date2015-11-26T18:01:18Z
dc.date2014-08-01T18:19:03Z
dc.date2015-11-26T18:01:18Z
dc.date.accessioned2018-03-29T00:42:49Z
dc.date.available2018-03-29T00:42:49Z
dc.identifierHistopathology. Wiley-blackwell, v. 64, n. 6, n. 880, n. 889, 2014.
dc.identifier0309-0167
dc.identifier1365-2559
dc.identifierWOS:000333759500014
dc.identifier10.1111/his.12339
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77057
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77057
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291944
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionAims The morphological criteria for identification of intercalated duct lesions (IDLs) of salivary glands have been defined recently. It has been hypothesised that IDL could be a precursor of basal cell adenoma (BCA). BCAs show a variety of histological patterns, and the tubular variant is the one that presents the strongest resemblance with IDLs. The aim of this study was to analyse the morphological and immunohistochemical profiles of IDLs and BCAs classified into tubular and non-tubular subtypes, to determine whether or not IDL and tubular BCA represent distinct entities. Methods and results Eight IDLs, nine tubular BCAs and 19 non-tubular BCAs were studied. All tubular BCAs contained IDL-like areas, which represented 20-70% of the tumour. In non-tubular BCA, IDL-like areas were occasional and small (<5%). One patient presented IDLs, tubular BCAs and IDL/tubular BCA combined lesions. Luminal ductal cells of IDLs and tubular BCAs exhibited positivity for CK7, lysozyme, S100 and DOG1. In the non-tubular BCA group, few luminal cells exhibited such an immunoprofile; they were mainly CK14-positive. Basal/myoepithelial cells of IDLs, tubular BCAs and non-tubular BCAs were positive for CK14, calponin, alpha-SMA and p63; they were more numerous in BCA lesions. Conclusions IDL, tubular BCA and non-tubular BCA form a continuum of lesions in which IDLs are related closely to tubular BCA. In both, the immunoprofile of luminal and myoepithelial cells recapitulates the normal intercalated duct. The difference between the adenoma-like subset of IDLs and tubular BCA rests mainly on the larger numbers of myoepithelial cells in the latter. Our findings indicate that at least some BCAs can arise via IDLs.
dc.description64
dc.description6
dc.description880
dc.description889
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2011/51112-8, 2011/10366-7]
dc.languageen
dc.publisherWiley-blackwell
dc.publisherHoboken
dc.publisherEUA
dc.relationHistopathology
dc.relationHistopathology
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectintercalated duct lesion
dc.subjectimmunoprofile
dc.subjectbasal cell adenoma
dc.subjectEpithelial-myoepithelial Carcinoma
dc.subjectCanalicular Adenomas
dc.subjectHyperplasia
dc.subjectTumors
dc.titleTubular variant of basal cell adenoma shares immunophenotypical features with normal intercalated ducts and is closely related to intercalated duct lesions of salivary gland
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución