Structural abnormalities of the thalamus in juvenile myoclonic epilepsy

dc.creatorMory, SB
dc.creatorBetting, LE
dc.creatorFernandes, PT
dc.creatorLopes-Cendes, I
dc.creatorGuerreiro, MM
dc.creatorGuerreiro, CAM
dc.creatorCendes, F
dc.creatorLi, LM
dc.date2011
dc.dateAUG
dc.date2014-08-01T18:29:22Z
dc.date2015-11-26T18:01:13Z
dc.date2014-08-01T18:29:22Z
dc.date2015-11-26T18:01:13Z
dc.date.accessioned2018-03-29T00:42:44Z
dc.date.available2018-03-29T00:42:44Z
dc.identifierEpilepsy & Behavior. Academic Press Inc Elsevier Science, v. 21, n. 4, n. 407, n. 411, 2011.
dc.identifier1525-5050
dc.identifierWOS:000294104900014
dc.identifier10.1016/j.yebeh.2011.05.018
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79619
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79619
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291922
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionStudies have suggested that the thalamus is a key structure in the pathophysiology of juvenile myoclonic epilepsy. The objective of the present investigation was to examine the thalami of patients with juvenile myoclonic epilepsy using a combination of multiple structural neuroimaging modalities. The association between these techniques may reveal the mechanisms underlying juvenile myoclonic epilepsy and help to identify the neuroanatomical structures involved. Twenty-one patients with juvenile myoclonic epilepsy (13 women, mean age = 30 +/- 9 years) and a control group of 20 healthy individuals (10 women, mean age = 31 +/- 8 years) underwent MRI in a 2-T scanner. The volumetric three-dimensional sequence was used for structural investigation. Evaluation of the thalamus comprised voxel-based morphometry. automatic volumetry, and shape analysis. Comparisons were performed between patient and control groups. Voxel-based morphometry analysis identified areas of atrophy located in the anterior portion of the thalamus. Post hoc analysis of automatic volumetry did not reveal significant differences between the groups. Shape analysis disclosed differences between patients and controls in the anterior and inferior portions of the right thalamus and in the anterior portion of the left thalamus. The present investigation confirms that thalami of patients with juvenile myoclonic epilepsy are structurally abnormal with impairments located mainly in the anterior and inferior sections. (C) 2011 Elsevier Inc. All rights reserved.
dc.description21
dc.description4
dc.description407
dc.description411
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherAcademic Press Inc Elsevier Science
dc.publisherSan Diego
dc.publisherEUA
dc.relationEpilepsy & Behavior
dc.relationEpilepsy Behav.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectEpilepsy
dc.subjectNeuroimaging
dc.subjectJuvenile myoclonic epilepsy
dc.subjectMagnetic resonance
dc.subjectVolumetry
dc.subjectVoxel-based morphometry
dc.subjectIdiopathic Generalized Epilepsy
dc.subjectVoxel-based Morphometry
dc.subjectChildhood Absence Epilepsy
dc.subjectWave Discharges
dc.subjectMri Volumetry
dc.subjectSpike-wave
dc.subjectProton Mrs
dc.subjectEeg-fmri
dc.subjectSeizures
dc.subjectSegmentation
dc.titleStructural abnormalities of the thalamus in juvenile myoclonic epilepsy
dc.typeArtículos de revistas


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