TERNARY PHASE DIAGRAM OF KETAMINE ((R,S)-2-(2-CHLOROPHENYL)-2-METHYLAMINOCYCLOHEXANONE) IN ETHANOL AND PRELIMINARY STUDIES AIMING AT ENANTIOSELECTIVE CRYSTALLIZATION OF S-KETAMINE

dc.creatorBarros, GOF
dc.creatorTamagawa, RE
dc.creatorSantana, CC
dc.creatorMiranda, EA
dc.date2009
dc.dateAPR-JUN
dc.date2014-08-01T18:24:56Z
dc.date2015-11-26T18:01:08Z
dc.date2014-08-01T18:24:56Z
dc.date2015-11-26T18:01:08Z
dc.date.accessioned2018-03-29T00:42:39Z
dc.date.available2018-03-29T00:42:39Z
dc.identifierBrazilian Journal Of Chemical Engineering. Brazilian Soc Chemical Eng, v. 26, n. 2, n. 427, n. 434, 2009.
dc.identifier0104-6632
dc.identifierWOS:000267513900021
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78580
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78580
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291899
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCrystallization is an important industrial-scale process for the purification of enantiomers that depends on a phase diagram. In this work, the ternary phase diagram of R- and S-ketamine in ethanol was determined. The eutectic point indicated that crystallization of pure enantiomers from solutions containing more than 75% of the desired enantiomer is feasible. Solubility studies showed the feasibility of using temperature control to conduct the process. Batch crystallization of ketamine (S/R:80/20) solutions at 25 degrees C provided the isolation of S-ketamine (purity of 100%) with a yield from 65 to 70% and a productivity of 6.5 g/(1h).
dc.description26
dc.description2
dc.description427
dc.description434
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionUnicamp
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherBrazilian Soc Chemical Eng
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationBrazilian Journal Of Chemical Engineering
dc.relationBraz. J. Chem. Eng.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectKetamine
dc.subjectEnantioseparation
dc.subjectPhase diagrams
dc.subjectCrystallization
dc.subjectRacemic Mixtures
dc.subjectChromatography
dc.subjectSeparation
dc.subjectIsomers
dc.titleTERNARY PHASE DIAGRAM OF KETAMINE ((R,S)-2-(2-CHLOROPHENYL)-2-METHYLAMINOCYCLOHEXANONE) IN ETHANOL AND PRELIMINARY STUDIES AIMING AT ENANTIOSELECTIVE CRYSTALLIZATION OF S-KETAMINE
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución