Inherited risk factors for thrombophilia among children with Legg-Calve-Perthes disease

dc.creatorArruda, VR
dc.creatorBelangero, WD
dc.creatorOzelo, MC
dc.creatorOliveira, GB
dc.creatorPagnano, RG
dc.creatorVolpon, JB
dc.creatorAnnichino-Bizzacchi, JM
dc.date1999
dc.dateJAN-FEB
dc.date2014-08-01T18:32:51Z
dc.date2015-11-26T17:59:44Z
dc.date2014-08-01T18:32:51Z
dc.date2015-11-26T17:59:44Z
dc.date.accessioned2018-03-29T00:41:57Z
dc.date.available2018-03-29T00:41:57Z
dc.identifierJournal Of Pediatric Orthopaedics. Lippincott Williams & Wilkins, v. 19, n. 1, n. 84, n. 87, 1999.
dc.identifier0271-6798
dc.identifierWOS:000080114500019
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80558
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80558
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291723
dc.descriptionAn inherited tendency to hypercoagulability has been suggested as a cause of vascular thrombosis resulting in Legg-Calve-Perthes disease (LCPD). Here we carried out an investigation of the most common inherited risk factors for hypercoagulability including the mutation in the factor V gene (factor V Leiden), the transition 20.210 G-->A in the prothrombin gene, and also the homozygosity for the 677C-->T transition in the methylenetetrahydrofolate reductase gene (MTHFR). The investigation was carried out among 61 Brazilian children with LCPD, who were compared with 296 individuals from the general population. The prevalence of the factor V Leiden mutation was higher in LCPD patients than in the controls (4.9 vs. 0.7%; p = 0.03). However, no patient had the prothrombin gene variant, and no difference was found between patients and controls when homozygosity for MTHFR-T (3.2 vs. 2.6%;p = 0.63) was determined. These data suggest that in our population, the heterozygosity for factor V Leiden was the only inherited risk factor associated with the development of LCPD.
dc.description19
dc.description1
dc.description84
dc.description87
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationJournal Of Pediatric Orthopaedics
dc.relationJ. Pediatr. Orthop.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectfactor V gene
dc.subjecthomocysteine
dc.subjecthypercoagulability
dc.subjectLegg-Calve-Perthes disease
dc.subjectprothrombin gene
dc.subjectActivated Protein-c
dc.subjectVenous Thrombosis
dc.subjectArterial-disease
dc.subjectMethylenetetrahydrofolate Reductase
dc.subjectProthrombin Gene
dc.subjectMutation
dc.subjectHyperhomocysteinemia
dc.subjectPrevalence
dc.subjectDeficiency
dc.subjectNecrosis
dc.titleInherited risk factors for thrombophilia among children with Legg-Calve-Perthes disease
dc.typeArtículos de revistas


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