The effect of ovariectomy and estradiol replacement on collagen and elastic fibers in the bladder of rats

dc.creatorDambros, M
dc.creatorPalma, PCR
dc.creatorMandarim-de-Lacerda, CA
dc.creatorMiyaoka, R
dc.creatorNetto, NR
dc.date2003
dc.dateJUN
dc.date2014-11-19T06:51:17Z
dc.date2015-11-26T17:59:44Z
dc.date2014-11-19T06:51:17Z
dc.date2015-11-26T17:59:44Z
dc.date.accessioned2018-03-29T00:41:57Z
dc.date.available2018-03-29T00:41:57Z
dc.identifierInternational Urogynecology Journal. Springer London Ltd, v. 14, n. 2, n. 108, n. 112, 2003.
dc.identifier0937-3462
dc.identifierWOS:000184030400008
dc.identifier10.1007/s00192-002-1023-2
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75116
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/75116
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75116
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291719
dc.descriptionThe authors quantified the collagen and elastic fibers in the bladder wall of ovariectomized rats with and without estradiol replacement. This study was conducted on 60 3-month-old Wistar rats. Group 1 remained intact; group 2 underwent bilateral ovariectomy and were sacrificed after 30 days; group 3 were sham operated and sacrificed after 30 days; group 4 had a bilateral ovariectomy and after 30 days were started on subcutaneous injections of 17beta-estradiol (10 mug/kg body weight) for 90 days; group 5 were sham operated and after 30 days were on started subcutaneous sesame oil replacement (0.2 ml/day) for 90 days; group 6 had a bilateral ovariectomy and after 30 days were started on subcutaneous sesame oil replacement (0.2 ml/day) for 90 days. Sirius red and Weigert's resorcin-fuchsin were used to stain collagen and elastic fibers on paraffin-embedded rat bladder sections. The M-42 grid system was used to quantitatively analyze the fibers. Ovariectomy had no effect on the volumetric density and absolute volume of the collagen and elastic fibers in the bladder wall of rats, or on the weight of the bladder. Estradiol replacement in castrated animals did not demonstrate any significant difference in the stereological parameters compared to the castrated group without hormonal replacement.
dc.description14
dc.description2
dc.description108
dc.description112
dc.languageen
dc.publisherSpringer London Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationInternational Urogynecology Journal
dc.relationInt. Urogynecol. J.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectbladder
dc.subjectestradiol
dc.subjectextracellular matrix
dc.subjectovariectomy
dc.subjectrats
dc.subjectLower Urinary-tract
dc.subjectDetrusor Smooth-muscle
dc.subjectSex-hormones
dc.subjectEstrogen
dc.subjectProgesterone
dc.subjectExpression
dc.subjectContractility
dc.subjectMenopause
dc.subjectReceptors
dc.subjectUrethra
dc.titleThe effect of ovariectomy and estradiol replacement on collagen and elastic fibers in the bladder of rats
dc.typeArtículos de revistas


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