Increased sensory neuron apoptotic death 2 weeks after peripheral axotomy in C57BL/6J mice compared to A/J mice

dc.creatorPierucci, A
dc.creatorde Oliveira, ALR
dc.date2006
dc.date46447
dc.date2014-11-19T06:41:51Z
dc.date2015-11-26T17:58:24Z
dc.date2014-11-19T06:41:51Z
dc.date2015-11-26T17:58:24Z
dc.date.accessioned2018-03-29T00:41:53Z
dc.date.available2018-03-29T00:41:53Z
dc.identifierNeuroscience Letters. Elsevier Ireland Ltd, v. 396, n. 2, n. 127, n. 131, 2006.
dc.identifier0304-3940
dc.identifierWOS:000235861900010
dc.identifier10.1016/j.neulet.2005.11.024
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60035
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/60035
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60035
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291704
dc.descriptionPeripheral nerve transection results in a disconnection of the neuron from its target. As a result, a series of metabolic changes occur in the cell body that may cause neuronal death, mainly by apoptotic mechanisms. Although neurons from neonatal animals are the most susceptible, peripheral, lesion-induced, neuronal loss also occurs in adults, and is particularly evident in mouse sensory neurons. However, differences in genetic background cause particular isogenic strains of mice to react unevenly to peripheral nerve lesion. In this work, we investigated the occurrence of apoptosis as well as the ultrastructural changes in the dorsal root ganglion sensory neurons and satellite cells of C57BL/6J and A/J mice 2 weeks after ipsilateral sciatic nerve transection at the mid-thigh level. C57BL/6J mice displayed a stronger sensory neuron chromatolytic reaction that resulted in an increased loss of neurons when compared with isogenic A/J mice (p < 0.01). Additionally, most of the degenerating neurons displayed the classic features of apoptosis. These findings reinforced previous data obtained by the terminal-deoxynucleotidyl transferase nick-end labeling (TUNEL) technique. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
dc.description396
dc.description2
dc.description127
dc.description131
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationNeuroscience Letters
dc.relationNeurosci. Lett.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectapoptosis
dc.subjectisogenic mice
dc.subjectaxotomy
dc.subjectDorsal-root-ganglia
dc.subjectSciatic-nerve Transection
dc.subjectSpinal-cord
dc.subjectCell-death
dc.subjectTransganglionic Degeneration
dc.subjectAxonal Regeneration
dc.subjectTime-course
dc.subjectRat
dc.subjectAdult
dc.subjectSurvival
dc.titleIncreased sensory neuron apoptotic death 2 weeks after peripheral axotomy in C57BL/6J mice compared to A/J mice
dc.typeArtículos de revistas


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